trans-2,3-epoxy-1,5-diphenyl-1-pentanone

Base Information

• Chemical Name: trans-2,3-epoxy-1,5-diphenyl-1-pentanone
• CAS No.: 84034-00-4
• Molecular Formula: C₁₇H₁₆O₂
• Molecular Weight: 252.313
• Mol file: 84034-00-4.mol

Synonyms:

Chemical Property of trans-2,3-epoxy-1,5-diphenyl-1-pentanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-2,3-epoxy-1,5-diphenyl-1-pentanone

There total 3 articles about trans-2,3-epoxy-1,5-diphenyl-1-pentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

3-phenyl-propionaldehyde (104-53-0) + diphenyl(phenylethynyl)selenium trifluoromethanesulfonate → trans-2,3-epoxy-1,5-diphenyl-1-pentanone (84033-99-8,84034-00-4)

Guidance literature:

With lithium hydroxide; silver trifluoromethanesulfonate; triethylamine; In dichloromethane; acetonitrile; at 20 ℃;

DOI:10.1016/j.tetlet.2004.08.036

Reference yield:

3-phenyl-propionaldehyde (104-53-0) + α-bromoacetophenone (70-11-1) → cis-2,3-epoxy-1,5-diphenyl-1-pentanone (84033-99-8,84034-00-4) + trans-2,3-epoxy-1,5-diphenyl-1-pentanone (84033-99-8,84034-00-4)

Guidance literature:

With perhydrodibenzo-18-crown-6; potassium fluoride; tin(II) trifluoromethanesulfonate; triethylamine; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, -78 deg C; 2.) DMF, 12 h;

DOI:10.1246/cl.1982.1601

Reference yield:

3-phenyl-propionaldehyde (104-53-0) + α-bromoacetophenone (70-11-1) → cis-2,3-epoxy-1,5-diphenyl-1-pentanone (84033-99-8,84034-00-4) + trans-2,3-epoxy-1,5-diphenyl-1-pentanone (84033-99-8,84034-00-4)

Guidance literature:

With perhydrodibenzo-18-crown-6; potassium fluoride; tin(II) trifluoromethanesulfonate; triethylamine; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, -78 deg C; 2.) DMF, 12 h;

DOI:10.1246/cl.1982.1601

upstream raw materials:

3-phenyl-propionaldehyde

α-bromoacetophenone