(1R,3aS,7aR)-1-((R)-5-Benzenesulfonyl-1-methyl-pentyl)-4-[2-[(3S,5R)-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-indene

Base Information

Chemical Name:(1R,3aS,7aR)-1-((R)-5-Benzenesulfonyl-1-methyl-pentyl)-4-[2-[(3S,5R)-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-indene
CAS No.:194232-11-6
Molecular Formula:C₄₃H₇₂O₄SSi₂
Molecular Weight:741.279
Hs Code.:

(1R,3aS,7aR)-1-((R)-5-Benzenesulfonyl-1-methyl-pentyl)-4-[2-[(3S,5R)-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-indene

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Chemical Property of (1R,3aS,7aR)-1-((R)-5-Benzenesulfonyl-1-methyl-pentyl)-4-[2-[(3S,5R)-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-indene

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Technology Process of (1R,3aS,7aR)-1-((R)-5-Benzenesulfonyl-1-methyl-pentyl)-4-[2-[(3S,5R)-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-indene

There total 5 articles about (1R,3aS,7aR)-1-((R)-5-Benzenesulfonyl-1-methyl-pentyl)-4-[2-[(3S,5R)-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 194232-11-6
(1R,3aS,7aR)-1-((R)-5-Benzenesulfonyl-1-methyl-pentyl)-4-[2-[(3S,5R)-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-indene

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / imidazole / dimethylformamide / 2.5 h / Ambient temperature

2: 91 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Ambient temperature

3: 87 percent / Et₃N, N,N-dimethylaminopyridine / CH₂Cl₂ / 16 h / Ambient temperature

4: 1.) Li₂CO₃, LiBr / 1.) DMF, 80 deg C, 1 h, 2.) DMF, 80 deg C, 2 h

With 1H-imidazole; dmap; lithium aluminium tetrahydride; lithium carbonate; triethylamine; lithium bromide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0039-128X(97)00040-8

Reference yield:

: 145372-43-6
1α-[(tert-butyldimethylsilyl)oxy]-24-(methoxycarbonyl)-25,26,27-trisnorvitamin D3 tert-butyldimethylsilyl ether

: 194232-11-6
(1R,3aS,7aR)-1-((R)-5-Benzenesulfonyl-1-methyl-pentyl)-4-[2-[(3S,5R)-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-indene

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Ambient temperature

2: 87 percent / Et₃N, N,N-dimethylaminopyridine / CH₂Cl₂ / 16 h / Ambient temperature

3: 1.) Li₂CO₃, LiBr / 1.) DMF, 80 deg C, 1 h, 2.) DMF, 80 deg C, 2 h

With dmap; lithium aluminium tetrahydride; lithium carbonate; triethylamine; lithium bromide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0039-128X(97)00040-8

Reference yield:

: 74029-72-4
(5Z,7E)-(1S,3R)-1,3-dihydroxy-23a-homo-9,10-secochola-5,7,10⁽¹⁹⁾-trien-24-oic acid methyl ester

: 194232-11-6
(1R,3aS,7aR)-1-((R)-5-Benzenesulfonyl-1-methyl-pentyl)-4-[2-[(3S,5R)-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-indene

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / imidazole / dimethylformamide / 2.5 h / Ambient temperature

2: 91 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Ambient temperature

3: 87 percent / Et₃N, N,N-dimethylaminopyridine / CH₂Cl₂ / 16 h / Ambient temperature

4: 1.) Li₂CO₃, LiBr / 1.) DMF, 80 deg C, 1 h, 2.) DMF, 80 deg C, 2 h

With 1H-imidazole; dmap; lithium aluminium tetrahydride; lithium carbonate; triethylamine; lithium bromide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0039-128X(97)00040-8