di-o-chlorophenyl 5'-O-bis(2,2,2-trichloroethyl)phosphoryl-3'-O-t-butyldimethylsilyladenylyl(2'-5')-3'-O-t-butyldimethylsilyladenylyl(2'-5')-2',3'-bis-O-(t-butyldimethylsilyl)adenosine

Base Information

Chemical Name:di-o-chlorophenyl 5'-O-bis(2,2,2-trichloroethyl)phosphoryl-3'-O-t-butyldimethylsilyladenylyl(2'-5')-3'-O-t-butyldimethylsilyladenylyl(2'-5')-2',3'-bis-O-(t-butyldimethylsilyl)adenosine
CAS No.:97205-07-7
Molecular Formula:C₇₀H₁₀₂Cl₈N₁₅O₁₉P₃Si₄
Molecular Weight:1946.56
Hs Code.:

di-o-chlorophenyl 5'-O-bis(2,2,2-trichloroethyl)phosphoryl-3'-O-t-butyldimethylsilyladenylyl(2'-5')-3'-O-t-butyldimethylsilyladenylyl(2'-5')-2',3'-bis-O-(t-butyldimethylsilyl)adenosine

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Chemical Property of di-o-chlorophenyl 5'-O-bis(2,2,2-trichloroethyl)phosphoryl-3'-O-t-butyldimethylsilyladenylyl(2'-5')-3'-O-t-butyldimethylsilyladenylyl(2'-5')-2',3'-bis-O-(t-butyldimethylsilyl)adenosine

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Technology Process of di-o-chlorophenyl 5'-O-bis(2,2,2-trichloroethyl)phosphoryl-3'-O-t-butyldimethylsilyladenylyl(2'-5')-3'-O-t-butyldimethylsilyladenylyl(2'-5')-2',3'-bis-O-(t-butyldimethylsilyl)adenosine

There total 2 articles about di-o-chlorophenyl 5'-O-bis(2,2,2-trichloroethyl)phosphoryl-3'-O-t-butyldimethylsilyladenylyl(2'-5')-3'-O-t-butyldimethylsilyladenylyl(2'-5')-2',3'-bis-O-(t-butyldimethylsilyl)adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₇₀H₁₀₂Cl₈N₁₅O₁₈P₃Si₄

: 97205-07-7
di-o-chlorophenyl 5'-O-bis(2,2,2-trichloroethyl)phosphoryl-3'-O-t-butyldimethylsilyladenylyl(2'-5')-3'-O-t-butyldimethylsilyladenylyl(2'-5')-2',3'-bis-O-(t-butyldimethylsilyl)adenosine

Guidance literature:: With iodine; In tetrahydrofuran; diethyl ether; at 25 ℃; for 0.25h;
DOI:10.1016/S0040-4039(00)89130-3

Reference yield:

: 41662-41-3
bis(2,2,2-trichloroethyl) phosphorochloridite

: 97226-63-6
di-o-chlorophenyl 3'-O-t-butyldimethylsilyladenylyl(2'-5')-3'-O-t-butyldimethylsilyladenylyl(2'-5')-2',3'-bis-O-(t-butyldimethylsilyl)adenosine

: 97205-07-7
di-o-chlorophenyl 5'-O-bis(2,2,2-trichloroethyl)phosphoryl-3'-O-t-butyldimethylsilyladenylyl(2'-5')-3'-O-t-butyldimethylsilyladenylyl(2'-5')-2',3'-bis-O-(t-butyldimethylsilyl)adenosine

Guidance literature:: With 2,6-dimethylpyridine; iodine; sodium hydrogencarbonate; Yield given. Multistep reaction; 1.) THF, -78 deg C, 1 h, 2.) THF, ether, RT, 15 min;

Reference yield:

: 97205-07-7
di-o-chlorophenyl 5'-O-bis(2,2,2-trichloroethyl)phosphoryl-3'-O-t-butyldimethylsilyladenylyl(2'-5')-3'-O-t-butyldimethylsilyladenylyl(2'-5')-2',3'-bis-O-(t-butyldimethylsilyl)adenosine

: C₆₆H₉₈Cl₂N₁₅O₁₉P₃Si₄^(2-)

Guidance literature:: With Chelex 100 resin (NH₄⁺ form); copper; acetylacetone; zinc; Multistep reaction; 1.) DMF, 60 deg C, 6 h, 2.) DMF, MeOH, H₂O, RT, 1 h;