C₄₃H₅₀N₅O₁₂P

Base Information

• Chemical Name: C₄₃H₅₀N₅O₁₂P
• CAS No.: 197021-74-2
• Molecular Formula: C₄₃H₅₀N₅O₁₂P
• Molecular Weight: 859.87
• Mol file: 197021-74-2.mol

Synonyms:

Chemical Property of C₄₃H₅₀N₅O₁₂P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₃H₅₀N₅O₁₂P

There total 12 articles about C₄₃H₅₀N₅O₁₂P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[5-(tert-butyldiphenylsilyl)-2,3-dideoxy-3-C-(formyl)-β-D-erythro-pentofuranosyl]thymine (146557-69-9) → C43H50N5O12P (197021-74-2)

Guidance literature:

Multi-step reaction with 10 steps

1: 97 percent / NaBH₄ / ethanol / 20 °C

2: 76 percent / MeP(+)(OPh)3I(-); 2,6-lutidine / dimethylformamide / 20 °C

3: 94 percent / KHMDS / tetrahydrofuran / -78 - 20 °C

4: 87 percent / Me₃SiCl; EtOH / CHCl₃ / 20 °C

5: 92 percent / Et₃N / aq. ethanol / 20 °C

6: 86 percent / DCC; DMAP / tetrahydrofuran / 20 °C

7: pyridine / 18 h / 20 °C

8: CHCl₃; methanol / Heating

9: 96 percent / TBAF / tetrahydrofuran / 0 °C

10: pyridine / 20 °C

With pyridine; 2,6-dimethylpyridine; dmap; sodium tetrahydroborate; chloro-trimethyl-silane; ethanol; MeP(+)(OPh)3I(-); tetrabutyl ammonium fluoride; potassium hexamethylsilazane; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; ethanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1055/s-2001-12328

Reference yield:

3'-O-tert-Butyldiphenylsilyl-5'-iodo-5'-deoxythymidine (156793-45-2) → C43H50N5O12P (197021-74-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 95 percent / NaN₃ / dimethylformamide / 5 h / 85 °C

2: pyridine / 18 h / 20 °C

3: CHCl₃; methanol / Heating

4: 96 percent / TBAF / tetrahydrofuran / 0 °C

5: pyridine / 20 °C

With pyridine; sodium azide; tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1055/s-2001-12328

Reference yield:

1-{(3'R,4'S)-5'-O-[(tert-butyl)diphenylsilyl]-2',3'-dideoxy-3'-C-(hydroxymethyl)-β-pentofuranosyl}thymine (146557-80-4) → C43H50N5O12P (197021-74-2)

Guidance literature:

Multi-step reaction with 9 steps

1: 76 percent / MeP(+)(OPh)3I(-); 2,6-lutidine / dimethylformamide / 20 °C

2: 94 percent / KHMDS / tetrahydrofuran / -78 - 20 °C

3: 87 percent / Me₃SiCl; EtOH / CHCl₃ / 20 °C

4: 92 percent / Et₃N / aq. ethanol / 20 °C

5: 86 percent / DCC; DMAP / tetrahydrofuran / 20 °C

6: pyridine / 18 h / 20 °C

7: CHCl₃; methanol / Heating

8: 96 percent / TBAF / tetrahydrofuran / 0 °C

9: pyridine / 20 °C

With pyridine; 2,6-dimethylpyridine; dmap; chloro-trimethyl-silane; ethanol; MeP(+)(OPh)3I(-); tetrabutyl ammonium fluoride; potassium hexamethylsilazane; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; ethanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1055/s-2001-12328

upstream raw materials:

4,4'-dimethoxytrityl chloride

C₂₂H₃₂N₅O₁₀P

1-[5-(tert-butyldiphenylsilyl)-2,3-dideoxy-3-C-(formyl)-β-D-erythro-pentofuranosyl]thymine

1-{(3'R,4'S)-5'-O-[(tert-butyl)diphenylsilyl]-2',3'-dideoxy-3'-C-(hydroxymethyl)-β-pentofuranosyl}thymine