156793-45-2

Upstream product

• 83467-48-5 1-[(2R,4S,5R)-4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 50-89-5 thymidine 
• 25953-14-4 1-((2R,4S,5S)-4-hydroxy-5-(iodomethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 

Downstream Products

• 206982-57-2 N⁶-benzoyl-5'-O-[(tert-butyl)diphenylsilyl]-2'-deoxy-3'-de(phosphinicooxy)adenylylmethylenesulfonylmethylene-(3'->5')-3'-O-[(tert-butyl)diphenylsilyl]-2',5'-dideoxythymidine 
• 206982-59-4 N⁶-benzoyl-2'-deoxy-3'-de(phosphinicooxy)-5'-O-(4,4'-dimethoxytrityl)adenylylmethylenesulfonylmethylene-(3'->5')-2',5'-dideoxythymidine 
• 206982-58-3 N⁶-benzoyl-2'-deoxy-3'-de(phosphinicooxy)adenylylmethylenesulfonylmethylene-(3'->5')-2',5'-dideoxythymidine 
• 176097-40-8 1-[(2R,4S,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-(2-iodo-ethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 197021-67-3 C₇₀H₈₄N₅O₁₂PSi₂ 
• 342793-91-3 C₅₅H₇₀N₅O₁₀PSi₂ 
• 342793-93-5 C₅₅H₇₀N₅O₁₀PSi₂ 
• 197021-62-8 C₅₄H₆₈N₅O₁₀PSi₂ 
• 197021-74-2 C₄₃H₅₀N₅O₁₂P 
• 342793-95-7 C₄₄H₅₂N₅O₁₂P 
• 146557-62-2 3'-O-tert-Butyldiphenylsilyl-5'-azido-5'-deoxythymidine 
• 176097-41-9 2-[(2R,3S,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethanesulfonic acid isopropyl ester 

Relevant academic research and scientific papers

Synthesis of a new hydroxyamino linked thymidine dimer via a radical C-C bond formation

An efficient synthesis of a thymidine nucleoside dimer [T-3'-β-O- N(CH3)-CH2-5'-T] has been accomplished via an intermolecular radical coupling reaction. The novel dimer contains an achiral and neutral backbone linkage which may have potential application in constructing backbone modified antisense oligonucleosides.

Four step synthesis of a 5′-deoxy-5′-iodomethylthymidine

The conversion of an alkylsulfonate to an iodide with triphenylphosphine/iodine in benzene has been performed for a nucleoside. Starting from thymidine, 3′-protected 5′-deoxy-5′-iodomethylthymidine was synthesized in 4 steps.