156793-45-2Relevant articles and documents
Synthesis of a new hydroxyamino linked thymidine dimer via a radical C-C bond formation
Sanghvi,Cook
, p. 859 - 862 (1995)
An efficient synthesis of a thymidine nucleoside dimer [T-3'-β-O- N(CH3)-CH2-5'-T] has been accomplished via an intermolecular radical coupling reaction. The novel dimer contains an achiral and neutral backbone linkage which may have potential application in constructing backbone modified antisense oligonucleosides.
Four step synthesis of a 5′-deoxy-5′-iodomethylthymidine
Baeschlin, Daniel K.,Daube, Michael,Blaettler, Monika O.,Benner, Steven A.,Richert, Clemens
, p. 1591 - 1592 (2007/10/03)
The conversion of an alkylsulfonate to an iodide with triphenylphosphine/iodine in benzene has been performed for a nucleoside. Starting from thymidine, 3′-protected 5′-deoxy-5′-iodomethylthymidine was synthesized in 4 steps.