Technology Process of 2-<3-benzyl-6-oxo-2-thia-4,7-diaza-(1R,5R)-bicyclo-<3.2.0>-hept-3-en-7-yl>-mono-benzhydryl malonate
There total 5 articles about 2-<3-benzyl-6-oxo-2-thia-4,7-diaza-(1R,5R)-bicyclo-<3.2.0>-hept-3-en-7-yl>-mono-benzhydryl malonate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1) NaIO4 / 1) H2O; 2) NEt3, DMF, 20 deg C
2: 65 percent Chromat. / MgSO4, (CH3O)3P / benzene / 40 h / Heating
3: 74 percent / KMnO4, MgSO4 / H2O; ethanol / 15 - 20 °C
4: 1) Triton B / 1) DMF, CH3OH, -30 deg C, 15 min; 0 deg C, 15 min; 2) DMF, 15 min, -30 deg C; 1 h, 0 deg C; 2 h, r. t.
5: 1) lithium hexamethyldisilazide-ether 1:1 complex / 1) THF, -60 deg C, 30 min; 2) -60 deg C, 30 min, without cooling, 1 h
With
potassium permanganate; sodium periodate; N-benzyl-trimethylammonium hydroxide; magnesium sulfate; lithium hexamethyldisilazane; phosphorous acid trimethyl ester;
In
ethanol; water; benzene;
DOI:10.1016/S0040-4020(01)92143-X
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 65 percent Chromat. / MgSO4, (CH3O)3P / benzene / 40 h / Heating
2: 74 percent / KMnO4, MgSO4 / H2O; ethanol / 15 - 20 °C
3: 1) Triton B / 1) DMF, CH3OH, -30 deg C, 15 min; 0 deg C, 15 min; 2) DMF, 15 min, -30 deg C; 1 h, 0 deg C; 2 h, r. t.
4: 1) lithium hexamethyldisilazide-ether 1:1 complex / 1) THF, -60 deg C, 30 min; 2) -60 deg C, 30 min, without cooling, 1 h
With
potassium permanganate; N-benzyl-trimethylammonium hydroxide; magnesium sulfate; lithium hexamethyldisilazane; phosphorous acid trimethyl ester;
In
ethanol; water; benzene;
DOI:10.1016/S0040-4020(01)92143-X
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 74 percent / KMnO4, MgSO4 / H2O; ethanol / 15 - 20 °C
2: 1) Triton B / 1) DMF, CH3OH, -30 deg C, 15 min; 0 deg C, 15 min; 2) DMF, 15 min, -30 deg C; 1 h, 0 deg C; 2 h, r. t.
3: 1) lithium hexamethyldisilazide-ether 1:1 complex / 1) THF, -60 deg C, 30 min; 2) -60 deg C, 30 min, without cooling, 1 h
With
potassium permanganate; N-benzyl-trimethylammonium hydroxide; magnesium sulfate; lithium hexamethyldisilazane;
In
ethanol; water;
DOI:10.1016/S0040-4020(01)92143-X
