Propanedioic acid, (phenylmethyl)-, bis(phenylmethyl) ester

Base Information

• Chemical Name: Propanedioic acid, (phenylmethyl)-, bis(phenylmethyl) ester
• CAS No.: 121191-42-2
• Molecular Formula: C24H22O4
• Molecular Weight: 374.436
• Mol file: 121191-42-2.mol

Synonyms:

Chemical Property of Propanedioic acid, (phenylmethyl)-, bis(phenylmethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanedioic acid, (phenylmethyl)-, bis(phenylmethyl) ester

There total 9 articles about Propanedioic acid, (phenylmethyl)-, bis(phenylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

malonic acid dibenzyl ester (15014-25-2) + benzyl bromide (100-39-0) → dibenzyl 2-benzylmalonate (121191-42-2)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 45 ℃; for 6h; Inert atmosphere;

DOI:10.1246/cl.2012.976

Reference yield: 78.0%

malonic acid dibenzyl ester (15014-25-2) + benzyl alcohol (100-51-6,185532-71-2) → dibenzyl 2-benzylmalonate (121191-42-2)

Guidance literature:

With carbonyl(dihydrido)tris(triphenylphosphine)ruthenium(II); piperdinium acetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; for 4h; Reflux;

DOI:10.15227/orgsyn.086.0028

Reference yield: 70.0%

Phenyl methylene propanedioic acid dibenzyl ester (7324-91-6) → dibenzyl 2-benzylmalonate (121191-42-2)

Guidance literature:

With 1,3-bis-(diphenylphosphino)propane; caesium carbonate; benzyl alcohol; bis(1,5-cyclooctadiene)diiridium(I) dichloride; In toluene; at 150 ℃; for 24h;

DOI:10.1039/b511053j

upstream raw materials:

malonic acid dibenzyl ester

benzyl bromide

2-benzyl-malonic acid dimethyl ester

benzyl alcohol

Downstream raw materials:

dibenzyl 2-benzyl-2-hydroxymalonate

dibenzyl 2-benzyl-2-hydroperoxymalonate

C₃₆H₃₇NO₆

(2RS,5S)-2-benzyl-5-<(tert-butyloxycarbonyl)amino>-7-methyl-4-oxooctanoic acid

Refernces

• 1、 Miyamura, Hiroyuki,Kobayashi, Shu. "α-Hydroxylation of 1,3-dicarbonyl compounds catalyzed by polymer-incarcerated gold nanoclusters with molecular oxygen". supporting information. p. 976 - 978. Retrieved 2012/10/30.
• 2、 Black, Phillip. J.,Cami-Kobeci, Gerta,Edwards, Michael G.,Slatford, Paul A.,Whittlesey, Michael K.,Williams, Jonathan M. J.. "Borrowing hydrogen: Iridium-catalysed reactions for the formation of C-C bonds from alcohols". . p. 116 - 125. Retrieved 2007/10/03.