methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate

Base Information

• Chemical Name: methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate
• CAS No.: 11002-83-8
• Molecular Formula: C₃₀H₃₅NO₁₀
• Molecular Weight: 569.609
• Mol file: 11002-83-8.mol

Synonyms:

Chemical Property of methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate

Chemical Property:

• Vapor Pressure: 1.46E-21mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate

There total 16 articles about methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9-epi-aklavinone 7-methyl ether (78773-17-8,78773-18-9,78773-19-0,78773-20-3) → aklavin (60504-57-6,11002-83-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 11 percent / potassium carbonate / methanol / 1.75 h / 65 °C

2: trifluoroacetic acid / Ambient temperature

3: 30 percent / p-toluenesulfonic acid monohydrate / benzene / 50 °C

4: sodium methoxide / methanol / 2 h / -20 °C

5: NaBH₃CN, AcOH / H₂O / 1 h / Ambient temperature

With sodium methylate; sodium cyanoborohydride; potassium carbonate; toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid; In methanol; water; benzene;

DOI:10.1021/ja00404a047

Reference yield:

7-epi-aklavinone 7-methyl ether (78773-17-8,78773-18-9,78773-19-0,78773-20-3) → aklavin (60504-57-6,11002-83-8)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid / Ambient temperature

2: 30 percent / p-toluenesulfonic acid monohydrate / benzene / 50 °C

3: sodium methoxide / methanol / 2 h / -20 °C

4: NaBH₃CN, AcOH / H₂O / 1 h / Ambient temperature

With sodium methylate; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid; In methanol; water; benzene;

DOI:10.1021/ja00404a047

Reference yield:

aklavinone 7-methyl ether (78773-17-8,78773-18-9,78773-19-0,78773-20-3) → aklavin (60504-57-6,11002-83-8)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid / Ambient temperature

2: 30 percent / p-toluenesulfonic acid monohydrate / benzene / 50 °C

3: sodium methoxide / methanol / 2 h / -20 °C

4: NaBH₃CN, AcOH / H₂O / 1 h / Ambient temperature

With sodium methylate; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid; In methanol; water; benzene;

DOI:10.1021/ja00404a047

upstream raw materials:

formaldehyd

N-demethylaklavin

(+)-aklavinone

(2S,3S,4S)-2-methyl-3-(4-nitrobenzoyloxy)-4-trifluoracetamido-3,4-dihydro-2H-pyran