4'-bromo-5-n-hexylsalicylanilide

Base Information

• Chemical Name: 4'-bromo-5-n-hexylsalicylanilide
• CAS No.: 78417-64-8
• Molecular Formula: C₁₉H₂₂BrNO₂
• Molecular Weight: 376.293
• Mol file: 78417-64-8.mol

Synonyms:

Chemical Property of 4'-bromo-5-n-hexylsalicylanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-bromo-5-n-hexylsalicylanilide

There total 5 articles about 4'-bromo-5-n-hexylsalicylanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Hexanoyl chloride (142-61-0) → 4'-bromo-5-n-hexylsalicylanilide (78417-64-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 77 percent / aluminum chloride / CS₂ / 12 h

2: Zn, aq. HCl / 20 h / Heating

3: aq. NaOH / 12 h / Heating

4: 1.) PCl₃ / 1.) chlorobenzene, reflux, 15 min, 2.) chlorobenzene, reflux, 3 h

With hydrogenchloride; sodium hydroxide; aluminium trichloride; zinc; phosphorus trichloride; In carbon disulfide;

DOI:10.1021/jm00142a023

Reference yield:

methyl salicylate (119-36-8,8024-54-2) → 4'-bromo-5-n-hexylsalicylanilide (78417-64-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 77 percent / aluminum chloride / CS₂ / 12 h

2: Zn, aq. HCl / 20 h / Heating

3: aq. NaOH / 12 h / Heating

4: 1.) PCl₃ / 1.) chlorobenzene, reflux, 15 min, 2.) chlorobenzene, reflux, 3 h

With hydrogenchloride; sodium hydroxide; aluminium trichloride; zinc; phosphorus trichloride; In carbon disulfide;

DOI:10.1021/jm00142a023

Reference yield:

methyl 5-n-hexanoylsalicylate (78417-95-5) → 4'-bromo-5-n-hexylsalicylanilide (78417-64-8)

Guidance literature:

Multi-step reaction with 3 steps

1: Zn, aq. HCl / 20 h / Heating

2: aq. NaOH / 12 h / Heating

3: 1.) PCl₃ / 1.) chlorobenzene, reflux, 15 min, 2.) chlorobenzene, reflux, 3 h

With hydrogenchloride; sodium hydroxide; zinc; phosphorus trichloride;

DOI:10.1021/jm00142a023

upstream raw materials:

5-n-hexylsalicylic acid

4-bromo-aniline

5-n-hexyl-salicylic acid methyl ester

methyl 5-n-hexanoylsalicylate

Refernces