4-{[(4-methylphenyl)sulfonyl]amino}butanoic acid

Base Information

• Chemical Name: 4-{[(4-methylphenyl)sulfonyl]amino}butanoic acid
• CAS No.: 1213-42-9
• Molecular Formula: C11H15NO4S
• Molecular Weight: 257.31
• Hs Code.: 2935009090
• Mol file: 1213-42-9.mol

Synonyms:4-(tosylamino)butyric acid;Tos-GABA-OH;4-(Toluol-4-sulfonylamino)-buttersaeure;N-(4'-toluenesulfonyl)-4-aminobutyric acid;Benzenesulfonamide,4-methyl-N-(3-oxobutyl);N-(3-oxobutyl)-p-toluenesulfonamide;4-(tosylamino)butan-2-one;4-(tosylamino)butanoic acid;4-methyl-N-(3-oxo-butyl)-benzenesulfonamide;4-(toluene-4-sulfonylamino)-butyric acid;

Chemical Property of 4-{[(4-methylphenyl)sulfonyl]amino}butanoic acid

Chemical Property:

• PSA: 91.85000
• LogP: 2.60980

Purity/Quality:

98%min ^*data from raw suppliers

4-{[(4-Methylphenyl)sulfonyl]amino}butanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-{[(4-Methylphenyl)sulfonyl]amino}butanoic Acid can be used as drugs for amnesia.

Technology Process of 4-{[(4-methylphenyl)sulfonyl]amino}butanoic acid

There total 4 articles about 4-{[(4-methylphenyl)sulfonyl]amino}butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

p-toluenesulfonyl chloride (98-59-9) + 4-amino-n-butyric acid (56-12-2) → 4-(tosylamino)butanoic acid (1213-42-9)

Guidance literature:

With sodium hydroxide; In diethyl ether; water; at 0 - 20 ℃; for 3h; Inert atmosphere;

Reference yield:

toluene-4-sulfonic acid (104-15-4) + 4-amino-n-butyric acid (56-12-2) → 4-(tosylamino)butanoic acid (1213-42-9)

Guidance literature:

In water; at 20 ℃; for 0.5h;

DOI:10.1074/jbc.RA118.006111

Reference yield:

4-butanolide (96-48-0) → 4-(tosylamino)butanoic acid (1213-42-9)

Guidance literature:

at 200 ℃;

upstream raw materials:

p-toluenesulfonyl chloride

4-amino-n-butyric acid

4-butanolide

toluene-4-sulfonic acid

Downstream raw materials:

N-tosylpyrrolidinone

3,8,16,21-tetratosyl-3,8,16,21,27,28-hexaazatricyclo<21.3.1.1^10,14>octaicosa-1(27),10(28),11,13,23,25-hexaene

2,6-bis<amino>methyl>pyridine

dimethyl δ,δ'-ditosylpyridine-2,6-di(δ-azahexanoate)