(S)-2-[4-(3-{2-[4-((S)-1,3-Bis-tert-butoxycarbonyl-propylcarbamoyl)-phenylcarbamoyl]-ethyldisulfanyl}-propionylamino)-benzoylamino]-pentanedioic acid di-tert-butyl ester

Base Information

Chemical Name:(S)-2-[4-(3-{2-[4-((S)-1,3-Bis-tert-butoxycarbonyl-propylcarbamoyl)-phenylcarbamoyl]-ethyldisulfanyl}-propionylamino)-benzoylamino]-pentanedioic acid di-tert-butyl ester
CAS No.:167767-93-3
Molecular Formula:C₄₆H₆₆N₄O₁₂S₂
Molecular Weight:931.182
Hs Code.:

(S)-2-[4-(3-{2-[4-((S)-1,3-Bis-tert-butoxycarbonyl-propylcarbamoyl)-phenylcarbamoyl]-ethyldisulfanyl}-propionylamino)-benzoylamino]-pentanedioic acid di-tert-butyl ester

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Chemical Property of (S)-2-[4-(3-{2-[4-((S)-1,3-Bis-tert-butoxycarbonyl-propylcarbamoyl)-phenylcarbamoyl]-ethyldisulfanyl}-propionylamino)-benzoylamino]-pentanedioic acid di-tert-butyl ester

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Technology Process of (S)-2-[4-(3-{2-[4-((S)-1,3-Bis-tert-butoxycarbonyl-propylcarbamoyl)-phenylcarbamoyl]-ethyldisulfanyl}-propionylamino)-benzoylamino]-pentanedioic acid di-tert-butyl ester

There total 1 articles about (S)-2-[4-(3-{2-[4-((S)-1,3-Bis-tert-butoxycarbonyl-propylcarbamoyl)-phenylcarbamoyl]-ethyldisulfanyl}-propionylamino)-benzoylamino]-pentanedioic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1119-62-6
3,3'-dithiobis(propionic acid)

: 76282-66-1
di-tert-butyl (S)-N-(p-aminobenzoyl)-glutamate

: 167767-93-3
(S)-2-[4-(3-{2-[4-((S)-1,3-Bis-tert-butoxycarbonyl-propylcarbamoyl)-phenylcarbamoyl]-ethyldisulfanyl}-propionylamino)-benzoylamino]-pentanedioic acid di-tert-butyl ester

Guidance literature:: With pyridine; phosphorus trichloride; for 5h; Ambient temperature;
DOI:10.1248/cpb.46.255

Reference yield:

: 167767-93-3
(S)-2-[4-(3-{2-[4-((S)-1,3-Bis-tert-butoxycarbonyl-propylcarbamoyl)-phenylcarbamoyl]-ethyldisulfanyl}-propionylamino)-benzoylamino]-pentanedioic acid di-tert-butyl ester

: (S)-2-[4-(3-Mercapto-propionylamino)-benzoylamino]-pentanedioic acid di-tert-butyl ester

Guidance literature:: With sulfuric acid; zinc; In methanol; dichloromethane; chloroform; for 0.25h; Ambient temperature;
DOI:10.1248/cpb.46.255

Reference yield:

: 167767-93-3
(S)-2-[4-(3-{2-[4-((S)-1,3-Bis-tert-butoxycarbonyl-propylcarbamoyl)-phenylcarbamoyl]-ethyldisulfanyl}-propionylamino)-benzoylamino]-pentanedioic acid di-tert-butyl ester

: (S)-2-{4-[3-(2,3-Bis-tetradecanoyloxy-propylsulfanyl)-propionylamino]-benzoylamino}-pentanedioic acid

Guidance literature:: Multi-step reaction with 4 steps

1: Zn, H₂SO₄ / methanol; CHCl₃; CH₂Cl₂ / 0.25 h / Ambient temperature

2: methanol; CHCl₃; CH₂Cl₂ / 5 h / 40 °C

3: 76 percent / DMAP / CH₂Cl₂ / 2 h / Ambient temperature

4: 100 percent / TFA / CH₂Cl₂ / 1 h / Ambient temperature

With dmap; sulfuric acid; trifluoroacetic acid; zinc; In methanol; dichloromethane; chloroform;
DOI:10.1248/cpb.46.255