Technology Process of 3-(pyridin-3-ylamino)-5-(quinolin-4-yl)phenol
There total 5 articles about 3-(pyridin-3-ylamino)-5-(quinolin-4-yl)phenol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 24 h / 90 °C / Inert atmosphere
2: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane; potassium acetate / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere
3: potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex / 1,4-dioxane; water / 100 °C / Inert atmosphere
4: dimethylsulfide; boron trifluoride diethyl etherate / dichloromethane / 0 - 5 °C
With
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; dimethylsulfide; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane; boron trifluoride diethyl etherate; potassium acetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate;
In
1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; toluene;
1: Buchwald-Hartwig amination / 2: Suzuki-Miyura coupling / 3: Suzuki coupling;
DOI:10.1021/jm100659v
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 24 h / 90 °C / Inert atmosphere
2: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane; potassium acetate / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere
3: potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex / 1,4-dioxane; water / 100 °C / Inert atmosphere
4: dimethylsulfide; boron trifluoride diethyl etherate / dichloromethane / 0 - 5 °C
With
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; dimethylsulfide; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane; boron trifluoride diethyl etherate; potassium acetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate;
In
1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; toluene;
1: Buchwald-Hartwig amination / 2: Suzuki-Miyura coupling / 3: Suzuki coupling;
DOI:10.1021/jm100659v
- Guidance literature:
-
Multi-step reaction with 3 steps
1: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane; potassium acetate / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere
2: potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex / 1,4-dioxane; water / 100 °C / Inert atmosphere
3: dimethylsulfide; boron trifluoride diethyl etherate / dichloromethane / 0 - 5 °C
With
potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; dimethylsulfide; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane; boron trifluoride diethyl etherate; potassium acetate;
In
1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;
1: Suzuki-Miyura coupling / 2: Suzuki coupling;
DOI:10.1021/jm100659v
