3-Pyridinamine, N-[3-bromo-5-[(4-methoxyphenyl)methoxy]phenyl]-

Base Information

Chemical Name:3-Pyridinamine, N-[3-bromo-5-[(4-methoxyphenyl)methoxy]phenyl]-
CAS No.:915410-95-6
Molecular Formula:C19H17BrN2O2
Molecular Weight:385.26
Hs Code.:

Synonyms:

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Chemical Property of 3-Pyridinamine, N-[3-bromo-5-[(4-methoxyphenyl)methoxy]phenyl]-

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 3-Pyridinamine, N-[3-bromo-5-[(4-methoxyphenyl)methoxy]phenyl]-

There total 4 articles about 3-Pyridinamine, N-[3-bromo-5-[(4-methoxyphenyl)methoxy]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 462-08-8
pyridin-3-ylamine

: 915410-93-4
1,3-dibromo-5-((4-methoxybenzyl)oxy)-benzene

: 915410-95-6
N-(3-bromo-5-(4-methoxybenzyloxy)phenyl)pyridin-3-amine

Guidance literature:: With sodium tert-butoxide; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 90 ℃; for 40h;

Reference yield:

: 6311-60-0
3,5-dibromonitrobenzene

: 915410-95-6
N-(3-bromo-5-(4-methoxybenzyloxy)phenyl)pyridin-3-amine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; oxygen; potassium hydroxide / tetramethylurea / 20 °C

2: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 24 h / 90 °C / Inert atmosphere

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tetrabutylammomium bromide; oxygen; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; potassium hydroxide; sodium t-butanolate; In toluene; tetramethylurea; 2: Buchwald-Hartwig amination;
DOI:10.1021/jm100659v

Reference yield:

: 827-94-1
2,6-dibromo-4-nitroaniline

: 915410-95-6
N-(3-bromo-5-(4-methoxybenzyloxy)phenyl)pyridin-3-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid; sodium nitrite / ethanol; water / 3.25 h / Heating / reflux

1.2: 0 °C

2.1: potassium hydroxide; tetrabutylammomium bromide; oxygen / tetramethylurea / 49 h / 20 °C

3.1: sodium t-butanolate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 40.17 h / 90 °C

With potassium hydroxide; sulfuric acid; tetrabutylammomium bromide; oxygen; sodium t-butanolate; sodium nitrite; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In ethanol; water; toluene; tetramethylurea; 3.1: Buchwald reaction;