C₁₆H₁₈N₂O₇PS^(1-)*Na⁽¹⁺⁾

Base Information

• Chemical Name: C₁₆H₁₈N₂O₇PS^(1-)*Na⁽¹⁺⁾
• CAS No.: 81227-78-3
• Molecular Formula: C₁₆H₁₈N₂O₇PS*Na
• Molecular Weight: 436.358
• Mol file: 81227-78-3.mol

Synonyms:

Chemical Property of C₁₆H₁₈N₂O₇PS^(1-)*Na⁽¹⁺⁾

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of C₁₆H₁₈N₂O₇PS^(1-)*Na⁽¹⁺⁾

There total 4 articles about C₁₆H₁₈N₂O₇PS^(1-)*Na⁽¹⁺⁾ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C36H34N2O8PS(1-)*Na(1+) (81227-77-2) → C16H18N2O7PS(1-)*Na(1+) (81227-78-3)

Guidance literature:

With acetic acid; for 6h; Ambient temperature;

DOI:10.1246/bcsj.54.3815

Reference yield:

cyclohexylammonium S,S-diphenyl phosphorodithioate (67941-87-1) → C16H18N2O7PS(1-)*Na(1+) (81227-78-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) 2,4,6-triisopropylbenzenesulfonyl chloride (TPS), pyridine / 1.) RT, 30 min, 2.) RT, 20 min

2: 81 percent / 0.2 M NaOH / dioxane / 0.25 h / Ambient temperature

3: 100 percent / 80percent AcOH / 6 h / Ambient temperature

With pyridine; sodium hydroxide; 2,4,6-triisopropylphenylsulfonyl chloride; acetic acid; In 1,4-dioxane;

DOI:10.1246/bcsj.54.3815

Reference yield:

5'-O-(4-monomethoxytrityl)-2'-deoxythymidine (42926-80-7) → C16H18N2O7PS(1-)*Na(1+) (81227-78-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) 2,4,6-triisopropylbenzenesulfonyl chloride (TPS), pyridine / 1.) RT, 30 min, 2.) RT, 20 min

2: 81 percent / 0.2 M NaOH / dioxane / 0.25 h / Ambient temperature

3: 100 percent / 80percent AcOH / 6 h / Ambient temperature

With pyridine; sodium hydroxide; 2,4,6-triisopropylphenylsulfonyl chloride; acetic acid; In 1,4-dioxane;

DOI:10.1246/bcsj.54.3815

upstream raw materials:

C₃₆H₃₄N₂O₈PS^(1-)*Na⁽¹⁺⁾

cyclohexylammonium S,S-diphenyl phosphorodithioate

5'-O-(4-monomethoxytrityl)-2'-deoxythymidine

O^5'-(4-methoxy-trityl)-P,P-dithio-[3']thymidylic acid S,S'-diphenyl ester