1-carbamoyl-3-cyclohexylmethoxy-6-(4-methylpiperazin-1-yl)sulfonyl-β-carboline

Base Information

• Chemical Name: 1-carbamoyl-3-cyclohexylmethoxy-6-(4-methylpiperazin-1-yl)sulfonyl-β-carboline
• CAS No.: 1174589-08-2
• Molecular Formula: C₂₄H₃₁N₅O₄S
• Molecular Weight: 485.607
• Mol file: 1174589-08-2.mol

Synonyms:

Chemical Property of 1-carbamoyl-3-cyclohexylmethoxy-6-(4-methylpiperazin-1-yl)sulfonyl-β-carboline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-carbamoyl-3-cyclohexylmethoxy-6-(4-methylpiperazin-1-yl)sulfonyl-β-carboline

There total 10 articles about 1-carbamoyl-3-cyclohexylmethoxy-6-(4-methylpiperazin-1-yl)sulfonyl-β-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 9H-pyrido[3,4-b]indole-3-carboxylate (74214-62-3) → 1-carbamoyl-3-cyclohexylmethoxy-6-(4-methylpiperazin-1-yl)sulfonyl-β-carboline (1174589-08-2)

Guidance literature:

Multi-step reaction with 8 steps

1: hydrazine hydrate / methanol / 6 h / Reflux

2: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 - 5 °C

3: hydrogenchloride / water / 0.5 h / Reflux

4: hydrogenchloride; sodium nitrite / 2.5 h / 0 - 5 °C

5: 1,4-diaza-bicyclo[2.2.2]octane; sodium hydride / 24 h / Reflux; Inert atmosphere

6: sulfuric acid; dihydrogen peroxide; iron(II) sulfate / water / 0.17 h / 10 - 15 °C

7: chlorosulfonic acid / 0 - 5 °C

8: water / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; chlorosulfonic acid; sulfuric acid; dihydrogen peroxide; sodium hydride; hydrazine hydrate; iron(II) sulfate; sodium nitrite; In methanol; water; 3: Curtius rearrangement / 6: Minisci reaction;

DOI:10.1080/00397911.2010.546552

Reference yield:

3-cyclohexylmethoxy-β-carboline (1174589-38-8) → 1-carbamoyl-3-cyclohexylmethoxy-6-(4-methylpiperazin-1-yl)sulfonyl-β-carboline (1174589-08-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; dihydrogen peroxide; iron(II) sulfate / water / 0.17 h / 10 - 15 °C

2: chlorosulfonic acid / 0 - 5 °C

3: water / 20 °C

With chlorosulfonic acid; sulfuric acid; dihydrogen peroxide; iron(II) sulfate; In water; 1: Minisci reaction;

DOI:10.1080/00397911.2010.546552

Reference yield:

1-carbamoyl-3-cyclohexylmethoxy-β-carboline (1174589-39-9) → 1-carbamoyl-3-cyclohexylmethoxy-6-(4-methylpiperazin-1-yl)sulfonyl-β-carboline (1174589-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorosulfonic acid / 0 - 5 °C

2: water / 20 °C

With chlorosulfonic acid; In water;

DOI:10.1080/00397911.2010.546552

upstream raw materials:

1-methyl-piperazine

1-carbamoyl-3-cyclohexylmethoxy-6-chlorosulfonyl-β-carboline

3-cyclohexylmethoxy-β-carboline

1-carbamoyl-3-cyclohexylmethoxy-β-carboline