Technology Process of (Z)-1-(3-hydroxypropyl)-3,3,5,5-tetramethyl-4-(1-methylethenyl)-1-cyclohexanol
There total 3 articles about (Z)-1-(3-hydroxypropyl)-3,3,5,5-tetramethyl-4-(1-methylethenyl)-1-cyclohexanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1) 9-BBN, 2) 6M NaOH, 30percent H2O2 / 1) hexane, 17 h, r.t.; 3 h, 70 deg C, 2) C2H5OH, 2 h, 50 deg C
2: 10 percent / CrO3 / pyridine; CH2Cl2 / 0.25 h
3: 1) Li, bromoacetal, 2) pyridinium tosylate / 1) light petroleum, ether, ultrasonic bath, 4 h, 0 deg C, 2) ethanol, 55 deg C, 3 h
With
chromium(VI) oxide; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide; pyridinium p-toluenesulfonate; lithium; Bromoacetaldehyde diethyl acetal;
In
pyridine; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 10 percent / CrO3 / pyridine; CH2Cl2 / 0.25 h
2: 1) Li, bromoacetal, 2) pyridinium tosylate / 1) light petroleum, ether, ultrasonic bath, 4 h, 0 deg C, 2) ethanol, 55 deg C, 3 h
With
chromium(VI) oxide; pyridinium p-toluenesulfonate; lithium; Bromoacetaldehyde diethyl acetal;
In
pyridine; dichloromethane;
- Guidance literature:
-
With
pyridinium p-toluenesulfonate; lithium; Bromoacetaldehyde diethyl acetal;
Yield given. Multistep reaction;
1) light petroleum, ether, ultrasonic bath, 4 h, 0 deg C, 2) ethanol, 55 deg C, 3 h;
