2,5-dioxopyrrolidin-1-yl-3-(((((S,Z)-3-((E)-2-((1R,3aS,7aR)-7a-methyl-1-((R)-6-methylheptan-2-yl)hexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)carbonyl)amino)propanoate

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Chemical Name:2,5-dioxopyrrolidin-1-yl-3-(((((S,Z)-3-((E)-2-((1R,3aS,7aR)-7a-methyl-1-((R)-6-methylheptan-2-yl)hexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)carbonyl)amino)propanoate
CAS No.:1620787-28-1
Molecular Formula:C₃₅H₅₂N₂O₆
Molecular Weight:596.808
Hs Code.:

2,5-dioxopyrrolidin-1-yl-3-(((((S,Z)-3-((E)-2-((1R,3aS,7aR)-7a-methyl-1-((R)-6-methylheptan-2-yl)hexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)carbonyl)amino)propanoate

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Chemical Property of 2,5-dioxopyrrolidin-1-yl-3-(((((S,Z)-3-((E)-2-((1R,3aS,7aR)-7a-methyl-1-((R)-6-methylheptan-2-yl)hexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)carbonyl)amino)propanoate

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Technology Process of 2,5-dioxopyrrolidin-1-yl-3-(((((S,Z)-3-((E)-2-((1R,3aS,7aR)-7a-methyl-1-((R)-6-methylheptan-2-yl)hexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)carbonyl)amino)propanoate

There total 2 articles about 2,5-dioxopyrrolidin-1-yl-3-(((((S,Z)-3-((E)-2-((1R,3aS,7aR)-7a-methyl-1-((R)-6-methylheptan-2-yl)hexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)carbonyl)amino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-97-0
vitamin D₃

: 1620787-28-1
2,5-dioxopyrrolidin-1-yl-3-(((((S,Z)-3-((E)-2-((1R,3aS,7aR)-7a-methyl-1-((R)-6-methylheptan-2-yl)hexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)carbonyl)amino)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / dichloromethane / 0.75 h / 0 °C / Inert atmosphere

1.2: 0.75 h / 0 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate / water; acetone; ethanol / 0 °C / Inert atmosphere

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / Inert atmosphere

With lithium hydroxide monohydrate; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water; acetone;
DOI:10.1021/ja505519b

Reference yield:

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 1620787-29-2
C₃₁H₄₉NO₄

: 1620787-28-1
2,5-dioxopyrrolidin-1-yl-3-(((((S,Z)-3-((E)-2-((1R,3aS,7aR)-7a-methyl-1-((R)-6-methylheptan-2-yl)hexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)carbonyl)amino)propanoate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 2h; Inert atmosphere;
DOI:10.1021/ja505519b