Technology Process of 6-(2-chlorobenzyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-d>azepine
There total 14 articles about 6-(2-chlorobenzyl)-5,6,7,8-tetrahydro-4H-thieno<2,3-d>azepine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride; tin(ll) chloride;
In
acetic acid;
at 65 ℃;
for 2h;
Yield given;
DOI:10.1002/jhet.5570220416
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 90 ℃;
for 4h;
Yield given;
DOI:10.1002/jhet.5570220416
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 85 percent / K2CO3 / H2O; CHCl3 / 4 h / Ambient temperature
2: 95 percent / K2CO3 / dimethylformamide / 4 h / 90 °C
3: 90 percent / 2N aq. NaOH / ethanol / Ambient temperature; overnight
4: PCl5 / 1,2-dichloro-ethane / 0.5 h / 60 °C
5: SnCl2 / 1,2-dichloro-ethane / 2 h / -10 °C
6: 85 percent / NaBH4 / ethanol / 1 h / Ambient temperature
7: pyrene, 0.1M tetrabutylammonium perchlorate / dimethylformamide / 0.5 h / cathode-mercury electrode, anode-graphite electrode; separation by membrane, ref. electrode-Ag/0.1M AgNO3, appl. pot.=-2.52 V
8: SnCl2*2H2O, 12 N HCl / acetic acid / 2 h / 65 °C
9: K2CO3 / dimethylformamide / 4 h / 90 °C
With
hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; pyrene; phosphorus pentachloride; tetrabutylammonium perchlorate; potassium carbonate; tin(ll) chloride;
In
ethanol; chloroform; water; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570220416