2-(4-FORMYL-2-METHOXYPHENOXY) ACETIC ACID, N-(2-CHLOROPHENYL)AMIDE

Base Information

• Chemical Name: 2-(4-FORMYL-2-METHOXYPHENOXY) ACETIC ACID, N-(2-CHLOROPHENYL)AMIDE
• CAS No.: 247592-73-0
• Molecular Formula: C₁₆H₁₄ClNO₄
• Molecular Weight: 319.744
• Mol file: 247592-73-0.mol

Synonyms:

Chemical Property of 2-(4-FORMYL-2-METHOXYPHENOXY) ACETIC ACID, N-(2-CHLOROPHENYL)AMIDE

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Formyl-2-methoxyphenoxy)acetic acidN-(2-chlorophenyl)amide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 2-(4-FORMYL-2-METHOXYPHENOXY) ACETIC ACID, N-(2-CHLOROPHENYL)AMIDE

There total 3 articles about 2-(4-FORMYL-2-METHOXYPHENOXY) ACETIC ACID, N-(2-CHLOROPHENYL)AMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H9ClO4 + o-chloroaniline (95-51-2) → N-(2-chlorophenyl)-2-(4-formyl-2-methoxyphenoxy)acetamide (247592-73-0)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 4.5h;

DOI:10.1016/j.bmcl.2021.128194

Reference yield:

vanillin (121-33-5,8014-42-4) → N-(2-chlorophenyl)-2-(4-formyl-2-methoxyphenoxy)acetamide (247592-73-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / water / 1.67 h / Reflux

2: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 12 h / 20 °C

3: sodium hydrogencarbonate / dichloromethane / 4.5 h / 20 °C

With thionyl chloride; sodium hydrogencarbonate; N,N-dimethyl-formamide; sodium hydroxide; In dichloromethane; water;

DOI:10.1016/j.bmcl.2021.128194

Reference yield:

3-methoxy-4-(2-oxopropoxy)benzaldehyde → N-(2-chlorophenyl)-2-(4-formyl-2-methoxyphenoxy)acetamide (247592-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 12 h / 20 °C

2: sodium hydrogencarbonate / dichloromethane / 4.5 h / 20 °C

With thionyl chloride; sodium hydrogencarbonate; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1016/j.bmcl.2021.128194

upstream raw materials:

vanillin

o-chloroaniline

Refernces