Technology Process of 5-(2-tert-butyldiphenylsilyloxyethoxymethyl)-3-methoxycarbonylpyridine
There total 7 articles about 5-(2-tert-butyldiphenylsilyloxyethoxymethyl)-3-methoxycarbonylpyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 97 percent / tetrahydrofuran; diethyl ether / 2 h / Ambient temperature
2: 69 percent / NaBH4 / ethanol / 1.) 0 deg C, 1 h, 2.) room temperature, 3 h, 3.) reflux, 10 h
3: 1.) HCl gas, 2.) SOCl2 / 1.) CH2Cl2, 5 min, 2.) reflux, 2 h
4: 61 percent / HOCH2CH2OH / toluene / 24 h / Ambient temperature
5: 91 percent / imidazole / dimethylformamide / 6 h / Ambient temperature
6: 1.) BuLi / 1.) THF, -78 deg C, 5 min
7: tetrahydrofuran; diethyl ether
With
1H-imidazole; hydrogenchloride; sodium tetrahydroborate; n-butyllithium; thionyl chloride; ethylene glycol;
In
tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1080/15257779408013225
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 69 percent / NaBH4 / ethanol / 1.) 0 deg C, 1 h, 2.) room temperature, 3 h, 3.) reflux, 10 h
2: 1.) HCl gas, 2.) SOCl2 / 1.) CH2Cl2, 5 min, 2.) reflux, 2 h
3: 61 percent / HOCH2CH2OH / toluene / 24 h / Ambient temperature
4: 91 percent / imidazole / dimethylformamide / 6 h / Ambient temperature
5: 1.) BuLi / 1.) THF, -78 deg C, 5 min
6: tetrahydrofuran; diethyl ether
With
1H-imidazole; hydrogenchloride; sodium tetrahydroborate; n-butyllithium; thionyl chloride; ethylene glycol;
In
tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1080/15257779408013225
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) HCl gas, 2.) SOCl2 / 1.) CH2Cl2, 5 min, 2.) reflux, 2 h
2: 61 percent / HOCH2CH2OH / toluene / 24 h / Ambient temperature
3: 91 percent / imidazole / dimethylformamide / 6 h / Ambient temperature
4: 1.) BuLi / 1.) THF, -78 deg C, 5 min
5: tetrahydrofuran; diethyl ether
With
1H-imidazole; hydrogenchloride; n-butyllithium; thionyl chloride; ethylene glycol;
In
tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1080/15257779408013225
