[2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-phosphonic acid benzyl ester (1S,2R,3R,4S,5S,6R)-2,3,5,6-tetrakis-benzyloxy-4-(4-methoxy-benzyloxy)-cyclohexyl ester

Base Information

Chemical Name:[2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-phosphonic acid benzyl ester (1S,2R,3R,4S,5S,6R)-2,3,5,6-tetrakis-benzyloxy-4-(4-methoxy-benzyloxy)-cyclohexyl ester
CAS No.:134039-24-0
Molecular Formula:C₅₆H₆₃O₁₁P
Molecular Weight:943.083
Hs Code.:

[2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-phosphonic acid benzyl ester (1S,2R,3R,4S,5S,6R)-2,3,5,6-tetrakis-benzyloxy-4-(4-methoxy-benzyloxy)-cyclohexyl ester

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Chemical Property of [2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-phosphonic acid benzyl ester (1S,2R,3R,4S,5S,6R)-2,3,5,6-tetrakis-benzyloxy-4-(4-methoxy-benzyloxy)-cyclohexyl ester

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Technology Process of [2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-phosphonic acid benzyl ester (1S,2R,3R,4S,5S,6R)-2,3,5,6-tetrakis-benzyloxy-4-(4-methoxy-benzyloxy)-cyclohexyl ester

There total 14 articles about [2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-phosphonic acid benzyl ester (1S,2R,3R,4S,5S,6R)-2,3,5,6-tetrakis-benzyloxy-4-(4-methoxy-benzyloxy)-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34361-60-9,55123-24-5,55123-26-7,62012-78-6,104873-71-4
1,2:4,5-dicyclohexylidene-myo-inositol

: 134039-24-0
[2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-phosphonic acid benzyl ester (1S,2R,3R,4S,5S,6R)-2,3,5,6-tetrakis-benzyloxy-4-(4-methoxy-benzyloxy)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: 68 percent / BaO/Ba(OH)2 / dimethylformamide / 72 h / 20 °C

2: 1) NaH

3: HOCH₂CH₂OH / CH₂Cl₂

4: 1) NaH

5: 0.05N HCl / methanol

6: 1) NaH

7: 1,5-cyclooctadiene-bis-IrPF₆, activated with H₂ / 1,2-dichloro-ethane

8: 0.1 HCl / CH₂Cl₂; methanol

9: 43 percent

10: 99 percent / 0.2N NaOH / dioxane; methanol; H₂O

11: dioxane / 0.25 h / 20 °C

12: N-methylimidazole / dioxane / 1 h / 20 °C

13: 1) BuLi / 1) THF, -78 deg C, 2) -40 deg C, 1 h

With 1-methyl-1H-imidazole; hydrogenchloride; barium dihydroxide; sodium hydroxide; n-butyllithium; (1,5-cyclooctadiene)bis(methyldiphenylphosphine) iridium hexafluorophosphate; hydrogen; sodium hydride; ethylene glycol; barium(II) oxide; In 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)92129-4

Reference yield:

: 100-39-0
benzyl bromide

: 134039-24-0
[2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-phosphonic acid benzyl ester (1S,2R,3R,4S,5S,6R)-2,3,5,6-tetrakis-benzyloxy-4-(4-methoxy-benzyloxy)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 1) NaH

2: 0.05N HCl / methanol

3: 1) NaH

4: 1,5-cyclooctadiene-bis-IrPF₆, activated with H₂ / 1,2-dichloro-ethane

5: 0.1 HCl / CH₂Cl₂; methanol

6: 43 percent

7: 99 percent / 0.2N NaOH / dioxane; methanol; H₂O

8: dioxane / 0.25 h / 20 °C

9: N-methylimidazole / dioxane / 1 h / 20 °C

10: 1) BuLi / 1) THF, -78 deg C, 2) -40 deg C, 1 h

With 1-methyl-1H-imidazole; hydrogenchloride; sodium hydroxide; n-butyllithium; (1,5-cyclooctadiene)bis(methyldiphenylphosphine) iridium hexafluorophosphate; hydrogen; sodium hydride; In 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4039(00)92129-4

Reference yield:

: 129879-48-7,129941-40-8,134107-70-3
(+/-)-1,2:4,5-di-O-cyclohexylidene-3-O-allyl-myo-inositol

: 134039-24-0
[2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-phosphonic acid benzyl ester (1S,2R,3R,4S,5S,6R)-2,3,5,6-tetrakis-benzyloxy-4-(4-methoxy-benzyloxy)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 1) NaH

2: HOCH₂CH₂OH / CH₂Cl₂

3: 1) NaH

4: 0.05N HCl / methanol

5: 1) NaH

6: 1,5-cyclooctadiene-bis-IrPF₆, activated with H₂ / 1,2-dichloro-ethane

7: 0.1 HCl / CH₂Cl₂; methanol

8: 43 percent

9: 99 percent / 0.2N NaOH / dioxane; methanol; H₂O

10: dioxane / 0.25 h / 20 °C

11: N-methylimidazole / dioxane / 1 h / 20 °C

12: 1) BuLi / 1) THF, -78 deg C, 2) -40 deg C, 1 h

With 1-methyl-1H-imidazole; hydrogenchloride; sodium hydroxide; n-butyllithium; (1,5-cyclooctadiene)bis(methyldiphenylphosphine) iridium hexafluorophosphate; hydrogen; sodium hydride; ethylene glycol; In 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4039(00)92129-4