1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-phenylpropyl)-3,5-pyridinedicarboxylic acid 3-methylester

Base Information

• Chemical Name: 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-phenylpropyl)-3,5-pyridinedicarboxylic acid 3-methylester
• CAS No.: 125599-27-1
• Molecular Formula: C₂₇H₃₁NO₆
• Molecular Weight: 465.546
• Mol file: 125599-27-1.mol

Synonyms:

Chemical Property of 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-phenylpropyl)-3,5-pyridinedicarboxylic acid 3-methylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-phenylpropyl)-3,5-pyridinedicarboxylic acid 3-methylester

There total 6 articles about 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-phenylpropyl)-3,5-pyridinedicarboxylic acid 3-methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-phenylpropyl)-3,5-pyridinecarboxylic acid 3-methyl-5-benzylester (170750-36-4) → 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-phenylpropyl)-3,5-pyridinedicarboxylic acid 3-methylester (125599-27-1,145943-71-1,145943-72-2)

Guidance literature:

In methanol; carbon palladium;

Reference yield:

1-Bromo-3-phenylpropane (637-59-2) → 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-phenylpropyl)-3,5-pyridinedicarboxylic acid 3-methylester (125599-27-1,145943-71-1,145943-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 65.2 percent / NaH / dimethylformamide / 1 h / 100 °C

2: 70 percent / H₂ / 5percent Pd/C / methanol / 2 h / Ambient temperature

With hydrogen; sodium hydride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.43.818

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-phenylpropyl)-3,5-pyridinedicarboxylic acid 3-methylester (125599-27-1,145943-71-1,145943-72-2)

Guidance literature:

Multi-step reaction with 4 steps

1: piperidine, acetic acid / benzene / 2 h / Heating

2: triethylamine / benzene / 3 h / Heating

3: 65.2 percent / NaH / dimethylformamide / 1 h / 100 °C

4: 70 percent / H₂ / 5percent Pd/C / methanol / 2 h / Ambient temperature

With piperidine; hydrogen; sodium hydride; acetic acid; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; benzene;

DOI:10.1248/cpb.43.818

upstream raw materials:

1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-phenylpropyl)-3,5-pyridinecarboxylic acid 3-methyl-5-benzylester

1-Bromo-3-phenylpropane

3,4-dimethoxy-benzaldehyde

2-[1-(3,4-Dimethoxy-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid benzyl ester