Technology Process of 1-butyl-6-fluoro-4-oxo-7-phenyl-1,4-dihydroquinoline-3-carboxylic acid
There total 6 articles about 1-butyl-6-fluoro-4-oxo-7-phenyl-1,4-dihydroquinoline-3-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sulfuric acid; nitric acid / 0 - 20 °C
2.1: methanol; iron / Reflux
3.1: toluene / Reflux
4.1: diphenylether / Reflux
5.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 24 h / 80 °C
6.1: palladium diacetate; potassium carbonate; triphenylphosphine / water; N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere
7.1: water; sodium hydroxide / 6 h / Reflux
7.2: 20 °C / pH 4
With
methanol; sulfuric acid; water; nitric acid; palladium diacetate; iron; potassium carbonate; triphenylphosphine; potassium iodide; sodium hydroxide;
In
diphenylether; water; N,N-dimethyl-formamide; toluene;
6.1: Suzuki reaction;
DOI:10.1021/jm101439s
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: palladium diacetate; potassium carbonate; triphenylphosphine / water; N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere
2.1: water; sodium hydroxide / 6 h / Reflux
2.2: 20 °C / pH 4
With
water; palladium diacetate; potassium carbonate; triphenylphosphine; sodium hydroxide;
In
water; N,N-dimethyl-formamide;
1.1: Suzuki reaction;
DOI:10.1021/jm101439s
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: toluene / Reflux
2.1: diphenylether / Reflux
3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 24 h / 80 °C
4.1: palladium diacetate; potassium carbonate; triphenylphosphine / water; N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere
5.1: water; sodium hydroxide / 6 h / Reflux
5.2: 20 °C / pH 4
With
water; palladium diacetate; potassium carbonate; triphenylphosphine; potassium iodide; sodium hydroxide;
In
diphenylether; water; N,N-dimethyl-formamide; toluene;
4.1: Suzuki reaction;
DOI:10.1021/jm101439s
