5-(Benzyloxy)-3-chlorobenzo[b]thiophene-2-carbonyl chloride

Base Information

Chemical Name:5-(Benzyloxy)-3-chlorobenzo[b]thiophene-2-carbonyl chloride
CAS No.:122024-71-9
Molecular Formula:C16H10Cl2O2S
Molecular Weight:337.226
Hs Code.:
DSSTox Substance ID:DTXSID20562892
Wikidata:Q82447185
Mol file:122024-71-9.mol

Synonyms:122024-71-9;5-(benzyloxy)-3-chlorobenzo[b]thiophene-2-carbonyl chloride;5-(Benzyloxy)-3-chlorobenzo[b]-thiophene-2-carbonyl chloride;3-chloro-5-phenylmethoxy-1-benzothiophene-2-carbonyl chloride;SCHEMBL9372198;DTXSID20562892;CKNPQZSCMFMRPI-UHFFFAOYSA-N;3-chloro-5-(benzyloxy)-benzo[b]thiophene-2-carbonyl chloride;5-(Benzyloxy)-3-chloro-1-benzothiophene-2-carbonyl chloride;3-chloro-5-(phenylmethoxy)benzo[b]thiophene-2-carbonyl chloride

Suppliers and Price of 5-(Benzyloxy)-3-chlorobenzo[b]thiophene-2-carbonyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
5-(Benzyloxy)-3-chlorobenzo[b]-thiophene-2-carbonyl chloride 95%
25g
$ 3819.00

Matrix Scientific
5-(Benzyloxy)-3-chlorobenzo[b]-thiophene-2-carbonyl chloride 95%
5g
$ 1273.00

Total 3 raw suppliers

Chemical Property of 5-(Benzyloxy)-3-chlorobenzo[b]thiophene-2-carbonyl chloride

Chemical Property:

PSA：54.54000
LogP:5.51270
XLogP3:5.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:335.9778561
Heavy Atom Count:21
Complexity:373

Purity/Quality:

95%-98% ^*data from raw suppliers

5-(Benzyloxy)-3-chlorobenzo[b]-thiophene-2-carbonyl chloride 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)COC2=CC3=C(C=C2)SC(=C3Cl)C(=O)Cl

Technology Process of 5-(Benzyloxy)-3-chlorobenzo[b]thiophene-2-carbonyl chloride

There total 6 articles about 5-(Benzyloxy)-3-chlorobenzo[b]thiophene-2-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 122024-75-3,138835-16-2
3-<3-(phenylmethoxy)phenyl>-2-propenoic acid

: 122024-71-9
3-Chloro-5-(phenylmethoxy)-benzo[b]thiophene-2-carbonyl chloride

Guidance literature:: With pyridine; thionyl chloride; N,N-dimethyl-formamide; In chlorobenzene; at 120 ℃; for 22h; Inert atmosphere;

Reference yield:

: 122024-75-3
C₁₆H₁₄O₃

: 122024-71-9
3-Chloro-5-(phenylmethoxy)-benzo[b]thiophene-2-carbonyl chloride

Guidance literature:: With pyridine; thionyl chloride; In N,N-dimethyl-formamide; chlorobenzene; at 120 ℃; for 22h;
DOI:10.1021/ml100230n

Reference yield:

: 100-39-0
benzyl bromide

: 122024-71-9
3-Chloro-5-(phenylmethoxy)-benzo[b]thiophene-2-carbonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 14 h / 20 °C

2: pyridine; thionyl chloride / N,N-dimethyl-formamide; chlorobenzene / 22 h / 120 °C

With pyridine; thionyl chloride; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; chlorobenzene; 2: Higa cyclization;
DOI:10.1021/ml100230n