2-{4-[({[2-(4-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]-methyl}[(5-methyl-1,3,4-oxadiazol-2-yl) methyl] amino)-methyl]-2,6-dimethylphenoxy}-2-methylpropanoic acid hydrochloride

Base Information

Chemical Name:2-{4-[({[2-(4-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]-methyl}[(5-methyl-1,3,4-oxadiazol-2-yl) methyl] amino)-methyl]-2,6-dimethylphenoxy}-2-methylpropanoic acid hydrochloride
CAS No.:1593269-92-1
Molecular Formula:C₂₉H₃₄N₄O₆*ClH
Molecular Weight:571.073
Hs Code.:

2-{4-[({[2-(4-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]-methyl}[(5-methyl-1,3,4-oxadiazol-2-yl) methyl] amino)-methyl]-2,6-dimethylphenoxy}-2-methylpropanoic acid hydrochloride

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Chemical Property of 2-{4-[({[2-(4-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]-methyl}[(5-methyl-1,3,4-oxadiazol-2-yl) methyl] amino)-methyl]-2,6-dimethylphenoxy}-2-methylpropanoic acid hydrochloride

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Technology Process of 2-{4-[({[2-(4-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]-methyl}[(5-methyl-1,3,4-oxadiazol-2-yl) methyl] amino)-methyl]-2,6-dimethylphenoxy}-2-methylpropanoic acid hydrochloride

There total 9 articles about 2-{4-[({[2-(4-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]-methyl}[(5-methyl-1,3,4-oxadiazol-2-yl) methyl] amino)-methyl]-2,6-dimethylphenoxy}-2-methylpropanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[4-[[[2-(4-methoxyphenyl)-5-methyloxazol-4-ylmethyl]-(5-methyl-[1,3,4]oxadiazol-2-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid ethyl ester

: 1593269-92-1
2-{4-[({[2-(4-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]-methyl}[(5-methyl-1,3,4-oxadiazol-2-yl) methyl] amino)-methyl]-2,6-dimethylphenoxy}-2-methylpropanoic acid hydrochloride

Guidance literature:: 2-[4-[[[2-(4-methoxyphenyl)-5-methyloxazol-4-ylmethyl]-(5-methyl-[1,3,4]oxadiazol-2-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoic acid ethyl ester; With water; sodium hydroxide; In methanol; at 20 ℃; Reflux;

With hydrogenchloride; In 1,4-dioxane;
DOI:10.1248/cpb.c13-00513

Reference yield:

: 639784-17-1
ethyl 2-(4-formyl-2,6-dimethylphenoxy)-2-methylpropanoate

: 1593269-92-1
2-{4-[({[2-(4-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]-methyl}[(5-methyl-1,3,4-oxadiazol-2-yl) methyl] amino)-methyl]-2,6-dimethylphenoxy}-2-methylpropanoic acid hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: magnesium sulfate / tetrahydrofuran / 4 h / Reflux

2: sodium tetrahydroborate / methanol / 4 h / 0 - 20 °C

3: acetonitrile / 4 h / 0 - 20 °C

4: trifluoroacetic acid / dichloromethane / 0 - 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 h / 20 °C

6: hexachloroethane; triethylamine; triphenylphosphine / dichloromethane / 20 °C

7: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 2 h / 0 °C

8: caesium carbonate; potassium iodide / acetonitrile / 75 °C

9: sodium hydroxide; water / methanol / 20 °C / Reflux

With sodium tetrahydroborate; hexachloroethane; water; magnesium sulfate; benzotriazol-1-ol; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; potassium iodide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.c13-00513

Reference yield:

: C₂₁H₃₁NO₅

: 1593269-92-1
2-{4-[({[2-(4-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]-methyl}[(5-methyl-1,3,4-oxadiazol-2-yl) methyl] amino)-methyl]-2,6-dimethylphenoxy}-2-methylpropanoic acid hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: sodium tetrahydroborate / methanol / 4 h / 0 - 20 °C

2: acetonitrile / 4 h / 0 - 20 °C

3: trifluoroacetic acid / dichloromethane / 0 - 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 h / 20 °C

5: hexachloroethane; triethylamine; triphenylphosphine / dichloromethane / 20 °C

6: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 2 h / 0 °C

7: caesium carbonate; potassium iodide / acetonitrile / 75 °C

8: sodium hydroxide; water / methanol / 20 °C / Reflux

With sodium tetrahydroborate; hexachloroethane; water; benzotriazol-1-ol; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; potassium iodide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.c13-00513