Propanoic acid, 2-[4-[[[2-(2-acetylhydrazino)-2-oxoethyl][(9H-fluoren-9-ylmethoxy)carbon yl]amino]methyl]-2,6-dimethylphenoxy]-2-methyl-, ethyl ester

Base Information

Chemical Name:Propanoic acid, 2-[4-[[[2-(2-acetylhydrazino)-2-oxoethyl][(9H-fluoren-9-ylmethoxy)carbon yl]amino]methyl]-2,6-dimethylphenoxy]-2-methyl-, ethyl ester
CAS No.:866641-07-8
Molecular Formula:C34H39N3O7
Molecular Weight:601.7
Hs Code.:

Propanoic acid,
2-[4-[[[2-(2-acetylhydrazino)-2-oxoethyl][(9H-fluoren-9-ylmethoxy)carbon
yl]amino]methyl]-2,6-dimethylphenoxy]-2-methyl-, ethyl ester

Synonyms:

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Chemical Property of Propanoic acid, 2-[4-[[[2-(2-acetylhydrazino)-2-oxoethyl][(9H-fluoren-9-ylmethoxy)carbon yl]amino]methyl]-2,6-dimethylphenoxy]-2-methyl-, ethyl ester

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Technology Process of Propanoic acid, 2-[4-[[[2-(2-acetylhydrazino)-2-oxoethyl][(9H-fluoren-9-ylmethoxy)carbon yl]amino]methyl]-2,6-dimethylphenoxy]-2-methyl-, ethyl ester

There total 6 articles about Propanoic acid, 2-[4-[[[2-(2-acetylhydrazino)-2-oxoethyl][(9H-fluoren-9-ylmethoxy)carbon yl]amino]methyl]-2,6-dimethylphenoxy]-2-methyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 866641-06-7
N-{4-[(1-ethoxy-2-methyl-1-oxopropan-2-yl)oxy]-3,5-dimethylbenzyl}-N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycine

: 1068-57-1
acetic acid hydrazide

: 866641-07-8
ethyl 2-[4-({[2-(2-acetylhydrazinyl)-2-oxoethyl][(9Hfluoren-9-ylmethoxy)carbonyl]amino}methyl)-2,6-dimethylphenoxydimethylphenoxy]-2-methylpropanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 20h;
DOI:10.1248/cpb.c13-00513

Reference yield:

: 639784-17-1
ethyl 2-(4-formyl-2,6-dimethylphenoxy)-2-methylpropanoate

: 866641-07-8
ethyl 2-[4-({[2-(2-acetylhydrazinyl)-2-oxoethyl][(9Hfluoren-9-ylmethoxy)carbonyl]amino}methyl)-2,6-dimethylphenoxydimethylphenoxy]-2-methylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: magnesium sulfate / tetrahydrofuran / 4 h / Reflux

2: sodium tetrahydroborate / methanol / 4 h / 0 - 20 °C

3: acetonitrile / 4 h / 0 - 20 °C

4: trifluoroacetic acid / dichloromethane / 0 - 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 h / 20 °C

With sodium tetrahydroborate; magnesium sulfate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.c13-00513

Reference yield:

: C₂₁H₃₁NO₅

: 866641-07-8
ethyl 2-[4-({[2-(2-acetylhydrazinyl)-2-oxoethyl][(9Hfluoren-9-ylmethoxy)carbonyl]amino}methyl)-2,6-dimethylphenoxydimethylphenoxy]-2-methylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / methanol / 4 h / 0 - 20 °C

2: acetonitrile / 4 h / 0 - 20 °C

3: trifluoroacetic acid / dichloromethane / 0 - 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 h / 20 °C

With sodium tetrahydroborate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.c13-00513