3-O-acetyl-26-hydroxy-26-O-tosylcholesterol

Base Information

• Chemical Name: 3-O-acetyl-26-hydroxy-26-O-tosylcholesterol
• CAS No.: 105078-99-7
• Molecular Formula: C₃₆H₅₄O₅S
• Molecular Weight: 598.888
• Mol file: 105078-99-7.mol

Synonyms:

Chemical Property of 3-O-acetyl-26-hydroxy-26-O-tosylcholesterol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-O-acetyl-26-hydroxy-26-O-tosylcholesterol

There total 9 articles about 3-O-acetyl-26-hydroxy-26-O-tosylcholesterol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Diosgenin monoacetate (1061-54-7,1180-12-7,33282-86-9,41336-81-6,75246-99-0,122405-26-9,122405-31-6) → 3-O-acetyl-26-hydroxy-26-O-tosylcholesterol (105078-99-7)

Guidance literature:

Multi-step reaction with 9 steps

1: 367 mg / zinc amalgam, zinc powder, conc. hydrochloric acid / ethanol; H₂O / 3 h / Heating

2: 120 mg / pyridine / diethyl ether / 3 h / Ambient temperature

3: 97 mg / Jones' reagent / acetone / 1.5 h

4: 288 mg / 1percent potassium hydroxide / methanol / 2 h / Heating

5: 1.) hydrazine hydrochloride, hydrazine hydrate, 2.) potassium hydroxide / 1.) 130 deg C, 1.5 h, triethyleneglycol; 2.) 210 deg C, 3.5 h

6: pyridine / 2 h / 80 °C

7: pyridine / 2 h / 80 °C

8: 26 mg / conc. hydrochloric acid / ethanol / 2 h / Ambient temperature

9: 20 mg / pyridine / 6 h / Ambient temperature

With pyridine; hydrogenchloride; potassium hydroxide; amalgamated zinc; jones' reagent; hydrazine hydrochloride; hydrazine hydrate; zinc; In pyridine; methanol; diethyl ether; ethanol; water; acetone;

Reference yield:

(25R)-cholest-5-ene-3β,26-diol (13095-61-9,13095-71-1,56845-83-1,80695-35-8,96553-74-1,96553-75-2,20380-11-4,26259-77-8) → 3-O-acetyl-26-hydroxy-26-O-tosylcholesterol (105078-99-7)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 2 h / 80 °C

2: pyridine / 2 h / 80 °C

3: 26 mg / conc. hydrochloric acid / ethanol / 2 h / Ambient temperature

4: 20 mg / pyridine / 6 h / Ambient temperature

With pyridine; hydrogenchloride; In pyridine; ethanol;

Reference yield:

(25R)-26-hydroxy-16-oxocholesterol (77611-30-4) → 3-O-acetyl-26-hydroxy-26-O-tosylcholesterol (105078-99-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) hydrazine hydrochloride, hydrazine hydrate, 2.) potassium hydroxide / 1.) 130 deg C, 1.5 h, triethyleneglycol; 2.) 210 deg C, 3.5 h

2: pyridine / 2 h / 80 °C

3: pyridine / 2 h / 80 °C

4: 26 mg / conc. hydrochloric acid / ethanol / 2 h / Ambient temperature

5: 20 mg / pyridine / 6 h / Ambient temperature

With pyridine; hydrogenchloride; potassium hydroxide; hydrazine hydrochloride; hydrazine hydrate; In pyridine; ethanol;

upstream raw materials:

toluene-4-sulfonic acid

(25R)-3β-acetoxy-cholest-5-en-26-ol

Diosgenin monoacetate

(25R)-cholest-5-ene-3β,26-diol