Technology Process of tert-Butyl-((2R,4R,6R)-2-methoxy-6-pentyl-tetrahydro-pyran-4-yloxy)-diphenyl-silane
There total 6 articles about tert-Butyl-((2R,4R,6R)-2-methoxy-6-pentyl-tetrahydro-pyran-4-yloxy)-diphenyl-silane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 92 percent / 1.)NaH, 2.)t-butyldiphenylsilyl chloride / tetrahydrofuran / 12 h / Ambient temperature
2: MeOH / p-toluenesulfonic acid / 12 h
3: 95 percent / CrO3-2Pyr / CH2Cl2 / 1 h
4: diethyl ether / -20 °C
5: 1.)TsCl 2.)lithium triethylborohydride / 1.)in pyridine
With
methanol; dipyridine chromium trioxide; sodium hydride; lithium triethylborohydride; p-toluenesulfonyl chloride; tert-butylchlorodiphenylsilane;
toluene-4-sulfonic acid;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(00)85585-9
- Guidance literature:
-
Multi-step reaction with 4 steps
1: MeOH / p-toluenesulfonic acid / 12 h
2: 95 percent / CrO3-2Pyr / CH2Cl2 / 1 h
3: diethyl ether / -20 °C
4: 1.)TsCl 2.)lithium triethylborohydride / 1.)in pyridine
With
methanol; dipyridine chromium trioxide; lithium triethylborohydride; p-toluenesulfonyl chloride;
toluene-4-sulfonic acid;
In
diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(00)85585-9
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 95 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature
2: 92 percent / 1.)NaH, 2.)t-butyldiphenylsilyl chloride / tetrahydrofuran / 12 h / Ambient temperature
3: MeOH / p-toluenesulfonic acid / 12 h
4: 95 percent / CrO3-2Pyr / CH2Cl2 / 1 h
5: diethyl ether / -20 °C
6: 1.)TsCl 2.)lithium triethylborohydride / 1.)in pyridine
With
methanol; lithium aluminium tetrahydride; dipyridine chromium trioxide; sodium hydride; lithium triethylborohydride; p-toluenesulfonyl chloride; tert-butylchlorodiphenylsilane;
toluene-4-sulfonic acid;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(00)85585-9
