(4-(4-phenyl-1H-1,2,3-triazol-1-yl)phenyl)methanol

Base Information

• Chemical Name: (4-(4-phenyl-1H-1,2,3-triazol-1-yl)phenyl)methanol
• CAS No.: 1338952-02-5
• Molecular Formula: C₁₅H₁₃N₃O
• Molecular Weight: 251.288
• Mol file: 1338952-02-5.mol

Synonyms:

Chemical Property of (4-(4-phenyl-1H-1,2,3-triazol-1-yl)phenyl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-(4-phenyl-1H-1,2,3-triazol-1-yl)phenyl)methanol

There total 4 articles about (4-(4-phenyl-1H-1,2,3-triazol-1-yl)phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-phenyl-1H-1,2,3-triazol-1-yl)benzaldehyde (1381887-01-9) → (4-(4-phenyl-1H-1,2,3-triazol-1-yl)phenyl)methanol (1338952-02-5)

Guidance literature:

4-(4-phenyl-1H-1,2,3-triazol-1-yl)benzaldehyde; With phenylsilane; potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.25h; Schlenk technique; Glovebox; Inert atmosphere;

With water; sodium hydroxide; In tetrahydrofuran; methanol; Schlenk technique; Glovebox;

DOI:10.1021/jo501505j

Reference yield:

4-azidobenzyl alcohol (31499-54-4) + phenylacetylene (536-74-3) → (4-(4-phenyl-1H-1,2,3-triazol-1-yl)phenyl)methanol (1338952-02-5)

Guidance literature:

With water; copper diacetate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In tert-butyl alcohol; for 1.5h; regiospecific reaction;

DOI:10.1002/asia.201100426

Reference yield:

4-formylphenylboronic acid, (87199-17-5) → (4-(4-phenyl-1H-1,2,3-triazol-1-yl)phenyl)methanol (1338952-02-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium fluoride; trimethylsilylazide; copper(l) chloride / methanol / Reflux; Inert atmosphere

2.1: C₃₉H₄₆ClCuN₂ / 2 h / 20 °C / Schlenk technique; Glovebox; Inert atmosphere

3.1: potassium tert-butylate; phenylsilane / tetrahydrofuran / 0.25 h / 20 °C / Schlenk technique; Glovebox; Inert atmosphere

3.2: Schlenk technique; Glovebox

With potassium fluoride; trimethylsilylazide; C₃₉H₄₆ClCuN₂; phenylsilane; potassium tert-butylate; copper(l) chloride; In tetrahydrofuran; methanol; 2.1: |Huisgen Cycloaddition;

DOI:10.1021/jo501505j

upstream raw materials:

4-azidobenzyl alcohol

phenylacetylene

4-formylphenylboronic acid,

4-azidobenzaldehyde