(2S)-benzyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxa-spiro[3.4]octan-7-yl)-methoxy)(naphthalen-1-yloxy)phosphoryl)amino)propanoate

Base Information

Chemical Name:(2S)-benzyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxa-spiro[3.4]octan-7-yl)-methoxy)(naphthalen-1-yloxy)phosphoryl)amino)propanoate
CAS No.:1255860-44-6
Molecular Formula:C₃₁H₃₂N₃O₁₀P
Molecular Weight:637.583
Hs Code.:

(2S)-benzyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxa-spiro[3.4]octan-7-yl)-methoxy)(naphthalen-1-yloxy)phosphoryl)amino)propanoate

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Chemical Property of (2S)-benzyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxa-spiro[3.4]octan-7-yl)-methoxy)(naphthalen-1-yloxy)phosphoryl)amino)propanoate

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Technology Process of (2S)-benzyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxa-spiro[3.4]octan-7-yl)-methoxy)(naphthalen-1-yloxy)phosphoryl)amino)propanoate

There total 12 articles about (2S)-benzyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxa-spiro[3.4]octan-7-yl)-methoxy)(naphthalen-1-yloxy)phosphoryl)amino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 906670-24-4
1-naphthyl(benzoxy-L-alaninyl)-phosphorochloridate

: 1255860-33-3
1-[(4R,5R,7R,8R)-8-hydroxy-7-(hydroxyl-methyl)-1,6-dioxaspiro[3.4]octan-5-yl]pyrimidine-2,4(1H,3H)-dione

: 1255860-44-6
(2S)-benzyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxa-spiro[3.4]octan-7-yl)-methoxy)(naphthalen-1-yloxy)phosphoryl)amino)propanoate

Guidance literature:: With 1-methyl-1H-imidazole; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/jm4015422

Reference yield:

: C₃₃H₃₂N₂O₇

: 1255860-44-6
(2S)-benzyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxa-spiro[3.4]octan-7-yl)-methoxy)(naphthalen-1-yloxy)phosphoryl)amino)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1: methanol; sodium methylate

2: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 20 °C

3: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C

4: pyridine / 2 h

5: sodium hydride / tetrahydrofuran / 2 h / 20 °C

6: palladium(II) hydroxide; hydrogen / tetrahydrofuran / 18 h / 25 °C / 775.74 Torr / Inert atmosphere

7: 1-methyl-1H-imidazole / tetrahydrofuran / 1 h / 20 °C

With pyridine; 1-methyl-1H-imidazole; methanol; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; hydrogen; sodium methylate; palladium(II) hydroxide; sodium hydride; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1021/jm4015422

Reference yield:

: 1255860-30-0
1-((2R,3R,4R,5R)-3-allyl-4-(benzyloxy)-5-(benzyloxymethyl)-3-hydroxytetra-hydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

: 1255860-44-6
(2S)-benzyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxa-spiro[3.4]octan-7-yl)-methoxy)(naphthalen-1-yloxy)phosphoryl)amino)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 20 °C

2: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C

3: pyridine / 2 h

4: sodium hydride / tetrahydrofuran / 2 h / 20 °C

5: palladium(II) hydroxide; hydrogen / tetrahydrofuran / 18 h / 25 °C / 775.74 Torr / Inert atmosphere

6: 1-methyl-1H-imidazole / tetrahydrofuran / 1 h / 20 °C

With pyridine; 1-methyl-1H-imidazole; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; hydrogen; palladium(II) hydroxide; sodium hydride; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1021/jm4015422