tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-2,6-diisopropyl-5-[(d3-methoxy)methyl]pyridin-3-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

Base Information

• Chemical Name: tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-2,6-diisopropyl-5-[(d3-methoxy)methyl]pyridin-3-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
• CAS No.: 916314-43-7
• Molecular Formula: C₃₃H₄₆FNO₅
• Molecular Weight: 558.707
• Mol file: 916314-43-7.mol

Synonyms:

Chemical Property of tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-2,6-diisopropyl-5-[(d3-methoxy)methyl]pyridin-3-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-2,6-diisopropyl-5-[(d3-methoxy)methyl]pyridin-3-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

There total 10 articles about tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-2,6-diisopropyl-5-[(d3-methoxy)methyl]pyridin-3-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-((diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-2,6-diisopropyl-5-[(d3-methoxy)methyl]pyridine (916314-42-6) + tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate (124752-23-4) → tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-2,6-diisopropyl-5-[(d3-methoxy)methyl]pyridin-3-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (916314-43-7)

Guidance literature:

3-((diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-2,6-diisopropyl-5-[(d3-methoxy)methyl]pyridine; With n-butyllithium; In tetrahydrofuran; hexane; at 3 - 5 ℃; for 0.833333h;

tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate; With 4 A molecular sieve; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 1.16667h;

DOI:10.1002/jlcr.1050

Reference yield:

(4-(4-fluorophenyl)-2,6-diisopropyl-5-[(d3-methoxy)methyl]pyridin-3-yl)methanol (916314-40-4) → tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-2,6-diisopropyl-5-[(d3-methoxy)methyl]pyridin-3-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (916314-43-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: phosphorous tribromide / CH₂Cl₂ / 1 h

2.1: toluene / 4 h / 116 °C

3.1: n-BuLi / hexane; tetrahydrofuran / 0.83 h / 3 - 5 °C

3.2: molecular sieves 4 Angstroem / tetrahydrofuran; hexane / 1.17 h / 0 - 20 °C

With n-butyllithium; phosphorus tribromide; In tetrahydrofuran; hexane; dichloromethane; toluene; 3.2: Horner olefination;

DOI:10.1002/jlcr.1050

Reference yield:

3-(bromomethyl)-4-(4-fluorophenyl)-2,6-diisopropyl-5-[(d3-methoxy)methyl]pyridine (916314-41-5) → tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-2,6-diisopropyl-5-[(d3-methoxy)methyl]pyridin-3-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (916314-43-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene / 4 h / 116 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 0.83 h / 3 - 5 °C

2.2: molecular sieves 4 Angstroem / tetrahydrofuran; hexane / 1.17 h / 0 - 20 °C

With n-butyllithium; In tetrahydrofuran; hexane; toluene; 2.2: Horner olefination;

DOI:10.1002/jlcr.1050

upstream raw materials:

3-((diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-2,6-diisopropyl-5-[(d3-methoxy)methyl]pyridine

tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate

(4-(4-fluorophenyl)-2,6-diisopropyl-5-[(d3-methoxy)methyl]pyridin-3-yl)methanol

3-(bromomethyl)-4-(4-fluorophenyl)-2,6-diisopropyl-5-[(d3-methoxy)methyl]pyridine

Downstream raw materials:

(4R,6S,E)-6-(2-(4-(4-fluorophenyl)-2,6-diisopropyl-5-[(d3-methoxy)methyl]-pyridin-3-yl)vinyl)-4-hydroxy-tetrahydropyran-2-one