8-(methylthio)-2'-deoxyadenosine

Base Information

• Chemical Name: 8-(methylthio)-2'-deoxyadenosine
• CAS No.: 29836-02-0
• Molecular Formula: C₁₁H₁₅N₅O₃S
• Molecular Weight: 297.338
• Mol file: 29836-02-0.mol

Synonyms:

Chemical Property of 8-(methylthio)-2'-deoxyadenosine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2’-Deoxy-8-methylthioadenosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-(methylthio)-2'-deoxyadenosine

There total 3 articles about 8-(methylthio)-2'-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

8-bromo-2'-deoxyadenosine (14985-44-5,90968-89-1) + sodium thiomethoxide (5188-07-8) → 8-(methylthio)-2'-deoxyadenosine (29836-02-0)

Guidance literature:

In water; N,N-dimethyl-formamide; at 20 ℃; for 5h;

DOI:10.1080/15257770701527109

Reference yield: 85.0%

sodium methylate (124-41-4) + sodium thiomethoxide (5188-07-8) → 8-(methylthio)-2'-deoxyadenosine (29836-02-0)

Guidance literature:

In N,N-dimethyl-formamide; at 110 ℃; for 4h;

DOI:10.1021/jm980657j

Reference yield:

2'-deoxy-8-mercaptoadenosine (17318-18-2) → 8-(methylthio)-2'-deoxyadenosine (29836-02-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)73300-4

upstream raw materials:

sodium methylate

sodium thiomethoxide

2'-deoxy-8-mercaptoadenosine

8-bromo-2'-deoxyadenosine

Downstream raw materials:

8-(methylsulfanyl)-9H-purin-6-amine