(R)-tert-butyl (4-formyl-3-methylpent-4-en-1-yl)(4-methoxybenzyl)carbamate

Base Information

• Chemical Name: (R)-tert-butyl (4-formyl-3-methylpent-4-en-1-yl)(4-methoxybenzyl)carbamate
• CAS No.: 1312472-97-1
• Molecular Formula: C₂₀H₂₉NO₄
• Molecular Weight: 347.455

Synonyms:

Chemical Property of (R)-tert-butyl (4-formyl-3-methylpent-4-en-1-yl)(4-methoxybenzyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl (4-formyl-3-methylpent-4-en-1-yl)(4-methoxybenzyl)carbamate

There total 7 articles about (R)-tert-butyl (4-formyl-3-methylpent-4-en-1-yl)(4-methoxybenzyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-propyl 5-((4-methoxybenzyl)amino)-3-methyl-5-oxopentanoate (1312472-94-8) → (R)-tert-butyl (4-formyl-3-methylpent-4-en-1-yl)(4-methoxybenzyl)carbamate (1312472-97-1)

Guidance literature:

Multi-step reaction with 5 steps

1: lithium hydroxide / tetrahydrofuran; water / 2 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 °C / Reflux; Inert atmosphere

3: triethylamine / dichloromethane / 0.5 h / 20 °C / Reflux; Inert atmosphere

4: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

5: N,N-dimethylammonium chloride / water / 24 h / 75 °C / sealed tube

With lithium aluminium tetrahydride; N,N-dimethylammonium chloride; sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/ol201448h

Reference yield:

(R)-3-methylglutaric acid mono-n-propyl ester (1046471-34-4) → (R)-tert-butyl (4-formyl-3-methylpent-4-en-1-yl)(4-methoxybenzyl)carbamate (1312472-97-1)

Guidance literature:

Multi-step reaction with 7 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3: lithium hydroxide / tetrahydrofuran; water / 2 h / 20 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 °C / Reflux; Inert atmosphere

5: triethylamine / dichloromethane / 0.5 h / 20 °C / Reflux; Inert atmosphere

6: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

7: N,N-dimethylammonium chloride / water / 24 h / 75 °C / sealed tube

With lithium aluminium tetrahydride; oxalyl dichloride; N,N-dimethylammonium chloride; sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/ol201448h

Reference yield:

3-methylglutaric anhydride (4166-53-4) → (R)-tert-butyl (4-formyl-3-methylpent-4-en-1-yl)(4-methoxybenzyl)carbamate (1312472-97-1)

Guidance literature:

Multi-step reaction with 8 steps

1: Amano Lipase PS / di-isopropyl ether / 16 h / 20 °C / Inert atmosphere; Enzymatic reaction

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4: lithium hydroxide / tetrahydrofuran; water / 2 h / 20 °C

5: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 °C / Reflux; Inert atmosphere

6: triethylamine / dichloromethane / 0.5 h / 20 °C / Reflux; Inert atmosphere

7: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

8: N,N-dimethylammonium chloride / water / 24 h / 75 °C / sealed tube

With lithium aluminium tetrahydride; oxalyl dichloride; Amano Lipase PS; N,N-dimethylammonium chloride; sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; dichloromethane; di-isopropyl ether; water;

DOI:10.1021/ol201448h

upstream raw materials:

3-methylglutaric anhydride

(R)-3-methylglutaric acid mono-n-propyl ester

(R)-propyl 5-((4-methoxybenzyl)amino)-3-methyl-5-oxopentanoate

C₁₄H₁₉NO₄

Downstream raw materials:

(R)-tert-butyl 4-methoxybenzyl(3-methyl-4-methylene-5-oxononyl)carbamate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1312472-97-1 (R)-tert-butyl (4-formyl-3-methylpent-4-en-1-yl)(4-methoxybenzyl)carbamate

Send

Send

Metric Ton KG G Pound L ML

Send

Send