(R)-propyl 5-((4-methoxybenzyl)amino)-3-methyl-5-oxopentanoate

Base Information

• Chemical Name: (R)-propyl 5-((4-methoxybenzyl)amino)-3-methyl-5-oxopentanoate
• CAS No.: 1312472-94-8
• Molecular Formula: C₁₇H₂₅NO₄
• Molecular Weight: 307.39
• Mol file: 1312472-94-8.mol

Synonyms:(R)-propyl 5-((4-methoxybenzyl)amino)-3-methyl-5-oxopentanoate

Chemical Property of (R)-propyl 5-((4-methoxybenzyl)amino)-3-methyl-5-oxopentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-propyl 5-((4-methoxybenzyl)amino)-3-methyl-5-oxopentanoate

There total 3 articles about (R)-propyl 5-((4-methoxybenzyl)amino)-3-methyl-5-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-3-methylglutaric acid mono-n-propyl ester (1046471-34-4) → (R)-propyl 5-((4-methoxybenzyl)amino)-3-methyl-5-oxopentanoate (1312472-94-8)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol201448h

Reference yield:

3-methylglutaric anhydride (4166-53-4) → (R)-propyl 5-((4-methoxybenzyl)amino)-3-methyl-5-oxopentanoate (1312472-94-8)

Guidance literature:

Multi-step reaction with 3 steps

1: Amano Lipase PS / di-isopropyl ether / 16 h / 20 °C / Inert atmosphere; Enzymatic reaction

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With oxalyl dichloride; Amano Lipase PS; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; di-isopropyl ether;

DOI:10.1021/ol201448h

Reference yield:

C9H15ClO3 + 4-methoxy-benzylamine (2393-23-9) → (R)-propyl 5-((4-methoxybenzyl)amino)-3-methyl-5-oxopentanoate (1312472-94-8)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol201448h

upstream raw materials:

3-methylglutaric anhydride

(R)-3-methylglutaric acid mono-n-propyl ester

4-methoxy-benzylamine

Downstream raw materials:

C₁₄H₁₉NO₄

(R)-tert-butyl (5-hydroxy-3-methylpentyl)(4-methoxybenzyl)carbamate

(R)-tert-butyl 4-methoxybenzyl(3-methyl-5-oxopentyl)carbamate

(R)-tert-butyl (4-formyl-3-methylpent-4-en-1-yl)(4-methoxybenzyl)carbamate