Technology Process of N-(tert-butyloxycarbonyl)-δ-benzyl<α-2H>aminoadipic acid methyl ester
There total 9 articles about N-(tert-butyloxycarbonyl)-δ-benzyl<α-2H>aminoadipic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 30 percent / conc. HCl / 0.67 h / Heating
2: 100 percent / triethylamine / dimethylformamide / 17 h
3: 93 percent / ethanol; diethyl ether / 0.75 h
4: H2 / 10percent Pd/C / methanol
5: N-methylmorpholine (NMM) / tetrahydrofuran / -30 °C
6: tetrahydrofuran; diethyl ether / 1.) -20 deg C, 1 h, 2.) RT, 21 h
7: silver benzoate, triethylamine / tetrahydrofuran / 18 h / 35 °C
With
4-methyl-morpholine; hydrogenchloride; hydrogen; silver benzoate; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00233a007
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 60 percent / D2O, NaOH, acetic anhydride / 32 h / 50 °C
2: 98 percent / 2 N NH4OH / H2O / 20 h / 37 °C / porcine kidney acylase
3: 30 percent / conc. HCl / 0.67 h / Heating
4: 100 percent / triethylamine / dimethylformamide / 17 h
5: 93 percent / ethanol; diethyl ether / 0.75 h
6: H2 / 10percent Pd/C / methanol
7: N-methylmorpholine (NMM) / tetrahydrofuran / -30 °C
8: tetrahydrofuran; diethyl ether / 1.) -20 deg C, 1 h, 2.) RT, 21 h
9: silver benzoate, triethylamine / tetrahydrofuran / 18 h / 35 °C
With
4-methyl-morpholine; hydrogenchloride; ammonium hydroxide; sodium hydroxide; hydrogen; water-d2; silver benzoate; acetic anhydride; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00233a007
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 98 percent / 2 N NH4OH / H2O / 20 h / 37 °C / porcine kidney acylase
2: 30 percent / conc. HCl / 0.67 h / Heating
3: 100 percent / triethylamine / dimethylformamide / 17 h
4: 93 percent / ethanol; diethyl ether / 0.75 h
5: H2 / 10percent Pd/C / methanol
6: N-methylmorpholine (NMM) / tetrahydrofuran / -30 °C
7: tetrahydrofuran; diethyl ether / 1.) -20 deg C, 1 h, 2.) RT, 21 h
8: silver benzoate, triethylamine / tetrahydrofuran / 18 h / 35 °C
With
4-methyl-morpholine; hydrogenchloride; ammonium hydroxide; hydrogen; silver benzoate; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00233a007
