raltegravir

Base Information

Chemical Name:raltegravir
CAS No.:1193687-87-4
Molecular Formula:C₂₀H₂₂N₆O₅
Molecular Weight:426.432
Hs Code.:2934990002

Synonyms:

Suppliers and Price of raltegravir

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-DefluoroRaltegravir
10mg
$ 1540.00

Total 8 raw suppliers

Chemical Property of raltegravir

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

4-DefluoroRaltegravir ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 4-Defluoro Raltegravir is an impurity of Raltegravir (R100300) which is a potent human immunodeficiency virus (HIV) integrase inhibitor.

Technology Process of raltegravir

There total 4 articles about raltegravir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 889131-28-6
5-methyl-1,3,4-oxadiazole-2-carboxylic acid chloride

: 1403457-41-9
2-(2-aminopropan-2-yl)-N-benzyl-1,6-dihydro-5-hydroxy-1-methyl-6-oxopyrimidine-4-carboxamide

: 1193687-87-4
raltegravir

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; acetonitrile; at 0 - 5 ℃; for 1h;
DOI:10.1021/op300077m

Reference yield:

: 1391918-11-8
C₂₄H₂₆N₄O₅

: 1193687-87-4
raltegravir

Guidance literature:: Multi-step reaction with 2 steps

1: 10% Pd/C; methanesulfonic acid; hydrogen / methanol / 50 - 55 °C / 1500.15 Torr / Autoclave

2: 4-methyl-morpholine / acetonitrile; tetrahydrofuran / 1 h / 0 - 5 °C

With 4-methyl-morpholine; methanesulfonic acid; 10% Pd/C; hydrogen; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/op300077m

Reference yield:

: 100-46-9
benzylamine

: 1193687-87-4
raltegravir

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 60 - 65 °C

2: 10% Pd/C; methanesulfonic acid; hydrogen / methanol / 50 - 55 °C / 1500.15 Torr / Autoclave

3: 4-methyl-morpholine / acetonitrile; tetrahydrofuran / 1 h / 0 - 5 °C

With 4-methyl-morpholine; methanesulfonic acid; 10% Pd/C; hydrogen; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/op300077m