C₂₂H₂₃Cl₂N₃O₂

Base Information

• Chemical Name: C₂₂H₂₃Cl₂N₃O₂
• CAS No.: 1338251-79-8
• Molecular Formula: C₂₂H₂₃Cl₂N₃O₂
• Molecular Weight: 432.35
• Mol file: 1338251-79-8.mol

Synonyms:

Chemical Property of C₂₂H₂₃Cl₂N₃O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₃Cl₂N₃O₂

There total 11 articles about C₂₂H₂₃Cl₂N₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H15Cl2N3O*ClH (1338251-66-3) → C22H23Cl2N3O2 (1338251-79-8)

Guidance literature:

With triethylamine; sodium iodide; In acetonitrile; at 80 ℃;

DOI:10.1016/j.bmcl.2011.07.087

Reference yield:

4-cyanopiperidine (4395-98-6) → C22H23Cl2N3O2 (1338251-79-8)

Guidance literature:

Multi-step reaction with 11 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: lithium diisopropyl amide / tetrahydrofuran / -78 - 20 °C

3: platinum(IV) oxide; hydrogen / acetic acid / 20 °C

4: sodium hydrogencarbonate / dichloromethane / 0 - 20 °C

5: water; sodium hydroxide / ethanol / Reflux

6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

7: pyridine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C

8: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

9: triethylamine / dichloromethane / 0 - 20 °C

10: hydrogenchloride / ethyl acetate

11: triethylamine; sodium iodide / acetonitrile / 80 °C

With pyridine; hydrogenchloride; platinum(IV) oxide; palladium 10% on activated carbon; water; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic anhydride; sodium iodide; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmcl.2011.07.087

Reference yield:

C12H21N3O2 (1207178-51-5) → C22H23Cl2N3O2 (1338251-79-8)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: hydrogenchloride / ethyl acetate

3: triethylamine; sodium iodide / acetonitrile / 80 °C

With hydrogenchloride; triethylamine; sodium iodide; In dichloromethane; ethyl acetate; acetonitrile;

DOI:10.1016/j.bmcl.2011.07.087

upstream raw materials:

4-cyanopiperidine

C₁₂H₂₁N₃O₂

1-tert-butyl 4-ethyl 4-(aminomethyl)piperidine-1,4-dicarboxylate

4-benzyloxycarbonylaminomethyl-4-ethoxycarbonylpiperidine-1-carboxylic acid tert-butyl ester