[(3S,4R)-1-Benzyl-4-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone

Base Information

• Chemical Name: [(3S,4R)-1-Benzyl-4-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone
• CAS No.: 175028-04-3
• Molecular Formula: C₂₉H₃₃F₃N₂O₃S
• Molecular Weight: 546.654
• Mol file: 175028-04-3.mol

Synonyms:

Chemical Property of [(3S,4R)-1-Benzyl-4-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(3S,4R)-1-Benzyl-4-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone

There total 3 articles about [(3S,4R)-1-Benzyl-4-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-3-(trifluoromethyl)cinnamoyl chloride (60689-14-7,64379-91-5) → [(3S,4R)-1-Benzyl-4-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-methanone (175028-04-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH, 2.) CuCl / 1.) toluene

2: CH₂Cl₂

With sodium hydride; copper(l) chloride; In dichloromethane;

DOI:10.1016/0960-894X(96)00015-7

Reference yield:

(2R)-bornane-10,2-sultam (94594-90-8,124224-04-0) → [(3S,4R)-1-Benzyl-4-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-methanone (175028-04-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH, 2.) CuCl / 1.) toluene

2: CH₂Cl₂

With sodium hydride; copper(l) chloride; In dichloromethane;

DOI:10.1016/0960-894X(96)00015-7

Reference yield:

N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine (93102-05-7) + (E)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-3-(3-trifluoromethyl-phenyl)-propenone (175028-03-2) → [(3S,4R)-1-Benzyl-4-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-methanone (175028-04-3) + [(3R,4S)-1-Benzyl-4-(3-trifluoromethyl-phenyl)-pyrrolidin-3-yl]-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-methanone

Guidance literature:

In dichloromethane; Yield given. Yields of byproduct given;

DOI:10.1016/0960-894X(96)00015-7

upstream raw materials:

N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine

(E)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-(3-trifluoromethyl-phenyl)-propenone

trans-3-(trifluoromethyl)cinnamoyl chloride

(2R)-bornane-10,2-sultam

Downstream raw materials:

(3S,4R)-4-(3-Trifluoromethyl-phenyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester