C₂₃H₂₃ClN₄O₄S₂

Base Information

• Chemical Name: C₂₃H₂₃ClN₄O₄S₂
• CAS No.: 1425941-53-2
• Molecular Formula: C₂₃H₂₃ClN₄O₄S₂
• Molecular Weight: 519.045
• Mol file: 1425941-53-2.mol

Synonyms:

Chemical Property of C₂₃H₂₃ClN₄O₄S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₃ClN₄O₄S₂

There total 5 articles about C₂₃H₂₃ClN₄O₄S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

oxetan-3-one (6704-31-0) + N-[1-{[3-(aminomethyl)phenyl]methyl}-4-methyloxy-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide hydrochloride (1240518-04-0) → C23H23ClN4O4S2 (1425941-53-2)

Guidance literature:

With sodium tris(acetoxy)borohydride; In tetrahydrofuran;

DOI:10.1021/jm301572h

Reference yield:

4-(methyloxy)-1H-indazol-3-amine (886362-07-8) → C23H23ClN4O4S2 (1425941-53-2)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium hydroxide / dimethyl sulfoxide / 0.42 h / 20 °C / Inert atmosphere

2: pyridine / 0.67 h / 20 °C / Inert atmosphere

3: lithium aluminium tetrahydride; hydrogenchloride / diethyl ether; tetrahydrofuran / 1 h / 10 - 20 °C / Inert atmosphere

4: sodium tris(acetoxy)borohydride / tetrahydrofuran

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; sodium tris(acetoxy)borohydride; potassium hydroxide; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;

DOI:10.1021/jm301572h

Reference yield:

3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}-benzonitrile (1240518-02-8) → C23H23ClN4O4S2 (1425941-53-2)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 0.67 h / 20 °C / Inert atmosphere

2: lithium aluminium tetrahydride; hydrogenchloride / diethyl ether; tetrahydrofuran / 1 h / 10 - 20 °C / Inert atmosphere

3: sodium tris(acetoxy)borohydride / tetrahydrofuran

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; sodium tris(acetoxy)borohydride; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jm301572h

upstream raw materials:

4-(methyloxy)-1H-indazol-3-amine

oxetan-3-one

N-[1-{[3-(aminomethyl)phenyl]methyl}-4-methyloxy-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide hydrochloride

3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}-benzonitrile