2-(1-Naphthyloxy)butanoic acid

Base Information

• Chemical Name: 2-(1-Naphthyloxy)butanoic acid
• CAS No.: 161904-60-5
• Molecular Formula: C₁₄H₁₄O₃
• Molecular Weight: 230.263
• DSSTox Substance ID: DTXSID701034946
• Mol file: 161904-60-5.mol

Synonyms:2-(1-naphthyloxy)butanoic acid;2-(naphthalen-1-yloxy)butanoic acid;161904-60-5;2-naphthalen-1-yloxybutanoic Acid;SCHEMBL8821208;DTXSID701034946;2-(naphthalen-1-yloxy)butanoicacid;STK501043;2-(Naphthalen-1-yloxy)-butyric acid;AKOS000102270;Butanoic acid, 2-(1-naphthalenyloxy)-;CS-0336963

Chemical Property of 2-(1-Naphthyloxy)butanoic acid

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 230.094294304
• Heavy Atom Count: 17
• Complexity: 264

Purity/Quality:

98%min ^*data from raw suppliers

2-(1-Naphthyloxy)butanoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCC(C(=O)O)OC1=CC=CC2=CC=CC=C21

Technology Process of 2-(1-Naphthyloxy)butanoic acid

There total 5 articles about 2-(1-Naphthyloxy)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

C15H16O3 (612047-45-7) → 2-α-naphthoxybutyric acid (161904-60-5)

Guidance literature:

With water; sodium hydroxide; for 4h; Heating;

DOI:10.1007/s10593-010-0465-6

Reference yield:

2-Bromobutyric acid (80-58-0) + α-naphthol (90-15-3) → 2-α-naphthoxybutyric acid (161904-60-5)

Guidance literature:

With sodium hydroxide; In ethanol; for 24h; Heating;

DOI:10.1021/jm00037a023

Reference yield:

sodium naphtholate (3019-88-3) → 2-α-naphthoxybutyric acid (161904-60-5)

Guidance literature:

Multi-step reaction with 2 steps

1: alcohol

2: bei der Verseifung

With ethanol;

upstream raw materials:

sodium naphtholate

2-bromobutyric acid ethyl ester

2-Bromobutyric acid

α-naphthol

Downstream raw materials:

(S)-2-[1]naphthyloxy-butyric acid

Refernces

• 1、 Gualtieri,Bottalico,Calandrella,Dei,Giovannoni,Mealli,Romanelli,Scapecchi,Teodori,Galeotti,Ghelardini,Giotti,Bartolini. "Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 2. 2-Phenoxy-, 2-(phenylthio)-, and 2-(phenylamino)alkanoic acid esters". . p. 1712 - 1719. Retrieved 2007/10/02.