2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2,6-difluorophenyl)pyridin-3-yl)methylamino)acetonitrile

Base Information

Chemical Name:2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2,6-difluorophenyl)pyridin-3-yl)methylamino)acetonitrile
CAS No.:1491169-36-8
Molecular Formula:C₂₂H₁₃F₈N₃
Molecular Weight:471.353
Hs Code.:

Synonyms:

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Chemical Property of 2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2,6-difluorophenyl)pyridin-3-yl)methylamino)acetonitrile

Chemical Property:

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Technology Process of 2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2,6-difluorophenyl)pyridin-3-yl)methylamino)acetonitrile

There total 8 articles about 2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2,6-difluorophenyl)pyridin-3-yl)methylamino)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: C₂₁H₁₄F₈N₂

: 1491169-36-8
2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2,6-difluorophenyl)pyridin-3-yl)methylamino)acetonitrile

Guidance literature:: at 0 - 20 ℃; for 24h;
DOI:10.1016/j.ejmech.2013.07.050

Reference yield:

: C₁₂H₉F₂NO

: 1491169-36-8
2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2,6-difluorophenyl)pyridin-3-yl)methylamino)acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / Reflux; Inert atmosphere

2: triphenylphosphine / water; tetrahydrofuran / 20 °C

3: hydrogenchloride

4: titanium(IV) isopropylate; triethylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

5: 24 h / 0 - 20 °C

With titanium(IV) isopropylate; hydrogenchloride; diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; 2: |Staudinger Azide Reduction;
DOI:10.1016/j.ejmech.2013.07.050

Reference yield:

: 162101-25-9
2,6-difluorophenylboronic acid

: 1491169-36-8
2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2,6-difluorophenyl)pyridin-3-yl)methylamino)acetonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine / hexane; toluene / 36 h / Inert atmosphere; Reflux

2: diisobutylaluminium hydride / toluene; dichloromethane / 1.5 h / -78 °C / Inert atmosphere

3: 1,8-diazabicyclo[5.4.0]undec-7-ene; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / Reflux; Inert atmosphere

4: triphenylphosphine / water; tetrahydrofuran / 20 °C

5: hydrogenchloride

6: titanium(IV) isopropylate; triethylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

7: 24 h / 0 - 20 °C

With titanium(IV) isopropylate; hydrogenchloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; diphenyl phosphoryl azide; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; water; toluene; 1: |Suzuki Coupling / 4: |Staudinger Azide Reduction;
DOI:10.1016/j.ejmech.2013.07.050