3,11-Diisopropoxy-2,12-dimethoxy-14-[4-methoxy-5-(methoxymethoxy)-2-methylphenyl]-6H-[1]benzopyrano-[4′,3′:4,5]pyrrolo[2,1-a]isoquinolin-6-one

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Chemical Name:3,11-Diisopropoxy-2,12-dimethoxy-14-[4-methoxy-5-(methoxymethoxy)-2-methylphenyl]-6H-[1]benzopyrano-[4′,3′:4,5]pyrrolo[2,1-a]isoquinolin-6-one
CAS No.:1454845-02-3
Molecular Formula:C₃₇H₃₉NO₉
Molecular Weight:641.718
Hs Code.:

3,11-Diisopropoxy-2,12-dimethoxy-14-[4-methoxy-5-(methoxymethoxy)-2-methylphenyl]-6H-[1]benzopyrano-[4′,3′:4,5]pyrrolo[2,1-a]isoquinolin-6-one

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Chemical Property of 3,11-Diisopropoxy-2,12-dimethoxy-14-[4-methoxy-5-(methoxymethoxy)-2-methylphenyl]-6H-[1]benzopyrano-[4′,3′:4,5]pyrrolo[2,1-a]isoquinolin-6-one

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Technology Process of 3,11-Diisopropoxy-2,12-dimethoxy-14-[4-methoxy-5-(methoxymethoxy)-2-methylphenyl]-6H-[1]benzopyrano-[4′,3′:4,5]pyrrolo[2,1-a]isoquinolin-6-one

There total 12 articles about 3,11-Diisopropoxy-2,12-dimethoxy-14-[4-methoxy-5-(methoxymethoxy)-2-methylphenyl]-6H-[1]benzopyrano-[4′,3′:4,5]pyrrolo[2,1-a]isoquinolin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1454844-98-4
3,11-diisopropoxy-2,12-dimethoxy-14-[4-methoxy-5-(methoxymethoxy)-2-methylphenyl]-8,9-dihydro-6H-[1]-benzopyrano[4′,3′:4,5]pyrrolo[2,1-a]isoquinolin-6-one

: 1454845-02-3,1456517-57-9,1456517-58-0
3,11-Diisopropoxy-2,12-dimethoxy-14-[4-methoxy-5-(methoxymethoxy)-2-methylphenyl]-6H-[1]benzopyrano-[4′,3′:4,5]pyrrolo[2,1-a]isoquinolin-6-one

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; for 24h; Inert atmosphere; Reflux;
DOI:10.1021/jm400719y

Reference yield:

: 1454845-07-8
1-bromo-4-methoxy-5-methoxymethoxy-2-methylbenzene

: 1454845-02-3,1456517-57-9,1456517-58-0
3,11-Diisopropoxy-2,12-dimethoxy-14-[4-methoxy-5-(methoxymethoxy)-2-methylphenyl]-6H-[1]benzopyrano-[4′,3′:4,5]pyrrolo[2,1-a]isoquinolin-6-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: tert.-butyl lithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; silver(l) oxide / 1,2-dimethoxyethane / 24 h / 85 °C / Inert atmosphere

3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 24 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butyl lithium; cesium fluoride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; silver(l) oxide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm400719y

Reference yield:

: 72791-83-4
2-methoxy-1-methoxymethoxy-4-methylbenzene

: 1454845-02-3,1456517-57-9,1456517-58-0
3,11-Diisopropoxy-2,12-dimethoxy-14-[4-methoxy-5-(methoxymethoxy)-2-methylphenyl]-6H-[1]benzopyrano-[4′,3′:4,5]pyrrolo[2,1-a]isoquinolin-6-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 5 h / 0 °C

2.1: tert.-butyl lithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; silver(l) oxide / 1,2-dimethoxyethane / 24 h / 85 °C / Inert atmosphere

4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 24 h / Inert atmosphere; Reflux

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butyl lithium; cesium fluoride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; silver(l) oxide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; 3.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm400719y