(11aS)-8-(3-(5-(4-(6-(3-chlorophenyl)-2-naphthoyl)piperazine-1-carbonyl)-2-methoxyphenoxy)propoxy)-7-methoxy-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one

Base Information

Chemical Name:(11aS)-8-(3-(5-(4-(6-(3-chlorophenyl)-2-naphthoyl)piperazine-1-carbonyl)-2-methoxyphenoxy)propoxy)-7-methoxy-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one
CAS No.:1334136-17-2
Molecular Formula:C₄₅H₄₃ClN₄O₇
Molecular Weight:787.312
Hs Code.:

(11aS)-8-(3-(5-(4-(6-(3-chlorophenyl)-2-naphthoyl)piperazine-1-carbonyl)-2-methoxyphenoxy)propoxy)-7-methoxy-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one

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Chemical Property of (11aS)-8-(3-(5-(4-(6-(3-chlorophenyl)-2-naphthoyl)piperazine-1-carbonyl)-2-methoxyphenoxy)propoxy)-7-methoxy-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one

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Technology Process of (11aS)-8-(3-(5-(4-(6-(3-chlorophenyl)-2-naphthoyl)piperazine-1-carbonyl)-2-methoxyphenoxy)propoxy)-7-methoxy-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one

There total 13 articles about (11aS)-8-(3-(5-(4-(6-(3-chlorophenyl)-2-naphthoyl)piperazine-1-carbonyl)-2-methoxyphenoxy)propoxy)-7-methoxy-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₉H₅₅ClN₄O₇S₂

: 1334136-17-2
(11aS)-8-(3-(5-(4-(6-(3-chlorophenyl)-2-naphthoyl)piperazine-1-carbonyl)-2-methoxyphenoxy)propoxy)-7-methoxy-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one

Guidance literature:: C₄₉H₅₅ClN₄O₇S₂; With calcium carbonate; mercury dichloride; In water; acetonitrile; at 20 ℃; for 12h;

With sodium hydrogencarbonate; In water; acetonitrile;
DOI:10.1002/cmdc.201100207

Reference yield:

: 1334138-64-5
C₄₉H₅₃ClN₄O₉S₂

: 1334136-17-2
(11aS)-8-(3-(5-(4-(6-(3-chlorophenyl)-2-naphthoyl)piperazine-1-carbonyl)-2-methoxyphenoxy)propoxy)-7-methoxy-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: tin(II) chloride dihdyrate / methanol / Reflux

1.2: pH 8

2.1: calcium carbonate; mercury dichloride / water; acetonitrile / 12 h / 20 °C

With tin(II) chloride dihdyrate; calcium carbonate; mercury dichloride; In methanol; water; acetonitrile;
DOI:10.1002/cmdc.201100207

Reference yield:

: 1334137-74-4
tert-butyl 4-(3-hydroxy-4-methoxybenzoyl)-1-piperazinecarboxylate

: 1334136-17-2
(11aS)-8-(3-(5-(4-(6-(3-chlorophenyl)-2-naphthoyl)piperazine-1-carbonyl)-2-methoxyphenoxy)propoxy)-7-methoxy-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: potassium carbonate / acetone / Reflux

4.1: potassium carbonate / acetone / Reflux

5.1: tin(II) chloride dihdyrate / methanol / Reflux

5.2: pH 8

6.1: calcium carbonate; mercury dichloride / water; acetonitrile / 12 h / 20 °C

With tin(II) chloride dihdyrate; potassium carbonate; triethylamine; trifluoroacetic acid; calcium carbonate; mercury dichloride; In methanol; dichloromethane; water; acetone; acetonitrile;
DOI:10.1002/cmdc.201100207