N-(4-(4-(3-(1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)ureido)-phenylamino)quinazolin-6-yl)-3-morpholinopropanamide trifluoroacetic acid

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Chemical Name:N-(4-(4-(3-(1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)ureido)-phenylamino)quinazolin-6-yl)-3-morpholinopropanamide trifluoroacetic acid
CAS No.:1446981-14-1
Molecular Formula:C₂HF₃O₂*C₃₅H₄₀N₁₀O₃
Molecular Weight:762.792
Hs Code.:

N-(4-(4-(3-(1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)ureido)-phenylamino)quinazolin-6-yl)-3-morpholinopropanamide trifluoroacetic acid

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Chemical Property of N-(4-(4-(3-(1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)ureido)-phenylamino)quinazolin-6-yl)-3-morpholinopropanamide trifluoroacetic acid

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Technology Process of N-(4-(4-(3-(1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)ureido)-phenylamino)quinazolin-6-yl)-3-morpholinopropanamide trifluoroacetic acid

There total 12 articles about N-(4-(4-(3-(1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)ureido)-phenylamino)quinazolin-6-yl)-3-morpholinopropanamide trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₀H₅₀N₁₀O₅

: 76-05-1
trifluoroacetic acid

: 1446981-14-1
N-(4-(4-(3-(1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)ureido)-phenylamino)quinazolin-6-yl)-3-morpholinopropanamide trifluoroacetic acid

Guidance literature:: C₅₀H₅₀N₁₀O₅; With morpholine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

trifluoroacetic acid;
DOI:10.1021/jm4004076

Reference yield:

: 1012883-12-3
C₁₆H₁₇Cl₃N₄O₄

: 1446981-14-1
N-(4-(4-(3-(1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)ureido)-phenylamino)quinazolin-6-yl)-3-morpholinopropanamide trifluoroacetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.08 h / 20 °C / Inert atmosphere

1.2: 24 h / 60 °C

2.1: ammonium formate; 5%-palladium/activated carbon / ethanol / 1 h / 70 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / water; 1,4-dioxane / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C / Inert atmosphere

5.2: 22 h / 20 °C

6.1: hydrogenchloride; acetic acid; iron / water; ethanol / 2.5 h / Reflux

7.1: 1-methyl-pyrrolidin-2-one / 1 h / 20 °C

8.1: morpholine / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / 20 °C

With morpholine; hydrogenchloride; 5%-palladium/activated carbon; ammonium formate; iron; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm4004076

Reference yield:

: 1012883-10-1
3-tert-butyl-1-(3-nitrophenyl)-1H-pyrazol-5-amine hydrochloride

: 1446981-14-1
N-(4-(4-(3-(1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)ureido)-phenylamino)quinazolin-6-yl)-3-morpholinopropanamide trifluoroacetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydroxide / water; ethyl acetate / 0 °C

1.2: 3.5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.08 h / 20 °C / Inert atmosphere

2.2: 24 h / 60 °C

3.1: ammonium formate; 5%-palladium/activated carbon / ethanol / 1 h / 70 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / water; 1,4-dioxane / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C / Inert atmosphere

6.2: 22 h / 20 °C

7.1: hydrogenchloride; acetic acid; iron / water; ethanol / 2.5 h / Reflux

8.1: 1-methyl-pyrrolidin-2-one / 1 h / 20 °C

9.1: morpholine / tetrahydrofuran; N,N-dimethyl-formamide / 0.25 h / 20 °C

With morpholine; hydrogenchloride; 5%-palladium/activated carbon; ammonium formate; iron; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm4004076