tert-butyl 4-(3-(3-tert-butyl-1-(3-nitrophenyl)-1H-pyrazol-5-yl)ureido)phenylcarbamate

Base Information

Chemical Name:tert-butyl 4-(3-(3-tert-butyl-1-(3-nitrophenyl)-1H-pyrazol-5-yl)ureido)phenylcarbamate
CAS No.:1446981-21-0
Molecular Formula:C₂₅H₃₀N₆O₅
Molecular Weight:494.55
Hs Code.:

Synonyms:tert-butyl 4-(3-(3-tert-butyl-1-(3-nitrophenyl)-1H-pyrazol-5-yl)ureido)phenylcarbamate

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Chemical Property of tert-butyl 4-(3-(3-tert-butyl-1-(3-nitrophenyl)-1H-pyrazol-5-yl)ureido)phenylcarbamate

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Technology Process of tert-butyl 4-(3-(3-tert-butyl-1-(3-nitrophenyl)-1H-pyrazol-5-yl)ureido)phenylcarbamate

There total 3 articles about tert-butyl 4-(3-(3-tert-butyl-1-(3-nitrophenyl)-1H-pyrazol-5-yl)ureido)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1012883-12-3
C₁₆H₁₇Cl₃N₄O₄

: 71026-66-9
N-(tert-butoxycarbonyl)-1,4-phenylenediamine

: 1446981-21-0
tert-butyl 4-(3-(3-tert-butyl-1-(3-nitrophenyl)-1H-pyrazol-5-yl)ureido)phenylcarbamate

Guidance literature:: N-(tert-butoxycarbonyl)-1,4-phenylenediamine; With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃; for 0.0833333h; Inert atmosphere;

C₁₆H₁₇Cl₃N₄O₄; In dimethyl sulfoxide; at 60 ℃; for 24h;
DOI:10.1021/jm4004076

Reference yield:

: 1012883-10-1
3-tert-butyl-1-(3-nitrophenyl)-1H-pyrazol-5-amine hydrochloride

: 1446981-21-0
tert-butyl 4-(3-(3-tert-butyl-1-(3-nitrophenyl)-1H-pyrazol-5-yl)ureido)phenylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water; ethyl acetate / 0 °C

1.2: 3.5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.08 h / 20 °C / Inert atmosphere

2.2: 24 h / 60 °C

With N-ethyl-N,N-diisopropylamine; sodium hydroxide; In water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jm4004076

Reference yield:

: 59997-51-2
trimethylacetylacetonitrile

: 1446981-21-0
tert-butyl 4-(3-(3-tert-butyl-1-(3-nitrophenyl)-1H-pyrazol-5-yl)ureido)phenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethanol / 12 h / 90 °C

2.1: sodium hydroxide / water; ethyl acetate / 0 °C

2.2: 3.5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.08 h / 20 °C / Inert atmosphere

3.2: 24 h / 60 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jm4004076