Methanesulfonic acid, trifluoro-, 4-phenyl-1-cyclohexen-1-yl ester

Base Information

• Chemical Name: Methanesulfonic acid, trifluoro-, 4-phenyl-1-cyclohexen-1-yl ester
• CAS No.: 122948-47-4
• Molecular Formula: C13H13F3O3S
• Molecular Weight: 306.306
• Mol file: 122948-47-4.mol

Synonyms:

Chemical Property of Methanesulfonic acid, trifluoro-, 4-phenyl-1-cyclohexen-1-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid, trifluoro-, 4-phenyl-1-cyclohexen-1-yl ester

There total 10 articles about Methanesulfonic acid, trifluoro-, 4-phenyl-1-cyclohexen-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-phenyl-4-cyclohexanone (4894-75-1) + phenylbis[(trifluoromethyl)sulfonyl]amine → 4-phenylcyclohex-1-enyl trifluoromethanesulfonate (122948-47-4)

Guidance literature:

1-phenyl-4-cyclohexanone; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at 20 ℃; for 1h;

phenylbis[(trifluoromethyl)sulfonyl]amine; In tetrahydrofuran; toluene; at 20 ℃; for 2h;

DOI:10.1002/chem.200401162

Reference yield: 91.0%

trifluoromethylsulfonic anhydride (358-23-6) + 1-phenyl-4-cyclohexanone (4894-75-1) → 4-phenylcyclohex-1-enyl trifluoromethanesulfonate (122948-47-4)

Guidance literature:

With caesium carbonate; In 1,4-dioxane; toluene; regioselective reaction;

DOI:10.1126/science.abl7854

Reference yield: 90.0%

N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) + 1-phenyl-4-cyclohexanone (4894-75-1) → 4-phenylcyclohex-1-enyl trifluoromethanesulfonate (122948-47-4)

Guidance literature:

1-phenyl-4-cyclohexanone; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 - 20 ℃; for 1h; Inert atmosphere;

N,N-phenylbistrifluoromethane-sulfonimide; In tetrahydrofuran; toluene; at -78 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/anie.201707517

upstream raw materials:

trifluoromethylsulfonic anhydride

1-phenyl-4-cyclohexanone

N,N-phenylbistrifluoromethane-sulfonimide

phenyl trifluoromethanesulfonamide

Downstream raw materials:

2-(4-phenylcyclohex-1-enylethynyl)phenylamine

(E)-2-Methyl-4-(4-phenyl-cyclohex-1-enyl)-but-3-en-2-ol

(E)-1-(4-Phenyl-cyclohex-1-enyl)-pent-1-en-3-ol

2-(4-Phenyl-cyclohex-1-enyl)-pent-1-en-3-ol

Refernces

• 1、 Wu, Zhao,Xu, Xiaolong,Wang, Jianchun,Dong, Guangbin. "Carbonyl 1,2-transposition through triflate-mediated a-amination". . p. 734 - 740. Retrieved 2021/11/16.
• 2、 -. "INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE". Paragraph 0324. . Retrieved 2020/03/23.