TN023991

Base Information

Chemical Name:TN023991
CAS No.:1802379-04-9
Molecular Formula:C₁₉H₁₉ClFNO₂
Molecular Weight:347.817
Hs Code.:

Synonyms:

Suppliers and Price of TN023991

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of TN023991

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of TN023991

There total 11 articles about TN023991 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: (3R,5R)-5-(5‘-chloro-2’-fluorobiphenyl-4-ylmethyl)-3-methyl-2-oxopyrrolidine-3-carboxylic acid

: 1802379-04-9
(3S,5R)-5-(5’-chloro-2’-fluorobiphenyl-4-ylmethyl)-3-hydroxymethyl-3-methylpyrrolidin-2-one

Guidance literature:: (3R,5R)-5-(5‘-chloro-2’-fluorobiphenyl-4-ylmethyl)-3-methyl-2-oxopyrrolidine-3-carboxylic acid; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -5 ℃; for 0.333333h; Inert atmosphere;

With sodium tetrahydroborate; water; In tetrahydrofuran; at -5 - 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: C₂₄H₂₅ClFNO₅

: 1802379-04-9
(3S,5R)-5-(5’-chloro-2’-fluorobiphenyl-4-ylmethyl)-3-hydroxymethyl-3-methylpyrrolidin-2-one

Guidance literature:: With sodium tetrahydroborate; water; In tetrahydrofuran; at -5 ℃; for 1h;

Reference yield:

: 79561-82-3
(2R)-3-(4-bromophenyl)-2-[[(tert-butoxy)carbonyl]amino]propanoic acid

: 1802379-04-9
(3S,5R)-5-(5’-chloro-2’-fluorobiphenyl-4-ylmethyl)-3-hydroxymethyl-3-methylpyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2.5 h / Inert atmosphere; Reflux

2.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / -10 - 20 °C / Inert atmosphere

3.1: sodium tetrahydroborate; acetic acid / dichloromethane / 3 h / -5 °C / Inert atmosphere

4.1: sodium carbonate / N,N-dimethyl-formamide; acetone / Inert atmosphere

5.1: cyclopentyl methyl ether; hydrogenchloride / -5 - 20 °C / Inert atmosphere

6.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / -5 °C / Inert atmosphere

6.2: 1 h / -5 - 20 °C

6.3: 2 h

With 4-methyl-morpholine; hydrogenchloride; dmap; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; cyclopentyl methyl ether; sodium carbonate; acetic acid; dicyclohexyl-carbodiimide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetone;