(13E,15E)-(3S,6S,9R,10R,11S,12S,21S)-3-(3-hydroxybenzyl)-6-isopropyl-10,12-dimethoxy-9,11-dimethyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

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Chemical Name:(13E,15E)-(3S,6S,9R,10R,11S,12S,21S)-3-(3-hydroxybenzyl)-6-isopropyl-10,12-dimethoxy-9,11-dimethyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone
CAS No.:1381808-22-5
Molecular Formula:C₃₄H₅₀N₄O₈
Molecular Weight:642.793
Hs Code.:

(13E,15E)-(3S,6S,9R,10R,11S,12S,21S)-3-(3-hydroxybenzyl)-6-isopropyl-10,12-dimethoxy-9,11-dimethyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

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Chemical Property of (13E,15E)-(3S,6S,9R,10R,11S,12S,21S)-3-(3-hydroxybenzyl)-6-isopropyl-10,12-dimethoxy-9,11-dimethyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

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Technology Process of (13E,15E)-(3S,6S,9R,10R,11S,12S,21S)-3-(3-hydroxybenzyl)-6-isopropyl-10,12-dimethoxy-9,11-dimethyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

There total 12 articles about (13E,15E)-(3S,6S,9R,10R,11S,12S,21S)-3-(3-hydroxybenzyl)-6-isopropyl-10,12-dimethoxy-9,11-dimethyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₀H₆₄N₄O₈Si

: 1381808-22-5
(13E,15E)-(3S,6S,9R,10R,11S,12S,21S)-3-(3-hydroxybenzyl)-6-isopropyl-10,12-dimethoxy-9,11-dimethyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 18.6667h;
DOI:10.1021/acs.jmedchem.6b01329

Reference yield:

: 1381810-40-7
(S)-1-{(S)-2-((S)-2-tert-butoxycarbonylamino-3-methylbutyrylamino)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]propionyl}hexahydropyridazine-3-carboxylic acid but-3-enyl ester

: 1381808-22-5
(13E,15E)-(3S,6S,9R,10R,11S,12S,21S)-3-(3-hydroxybenzyl)-6-isopropyl-10,12-dimethoxy-9,11-dimethyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

Guidance literature:: Multi-step reaction with 4 steps

1.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1.5 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.67 h / 0 °C

2.2: 0 - 20 °C

3.1: Grubbs catalyst first generation / dichloromethane / 20 h / Reflux

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18.67 h / 20 °C

With Grubbs catalyst first generation; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3.1: |Grubbs Olefin Metathesis;
DOI:10.1021/acs.jmedchem.6b01329

Reference yield:

: 1381810-47-4
(S)-1-{(S)-3-[3-(tert-butyldimethylsilanyloxy)phenyl]-2-[(S)-2-((E)-(2R,3R,4S,5S)-3,5-dimethoxy-2,4-dimethylnona-6,8-dienoylamino)-3-methylbutyrylamino]propionyl}hexahydropyridazine-3-carboxylic acid but-3-enyl ester

: 1381808-22-5
(13E,15E)-(3S,6S,9R,10R,11S,12S,21S)-3-(3-hydroxybenzyl)-6-isopropyl-10,12-dimethoxy-9,11-dimethyl-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetraone

Guidance literature:: Multi-step reaction with 2 steps

1: Grubbs catalyst first generation / dichloromethane / 20 h / Reflux

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 18.67 h / 20 °C

With Grubbs catalyst first generation; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; 1: |Grubbs Olefin Metathesis;
DOI:10.1021/acs.jmedchem.6b01329