Methyl-{5-methyl-2-[(E)-methylimino]-1,2-dihydro-benzo[cd]indol-6-yl}-[4-(morpholine-4-sulfonyl)-benzyl]-amine

Base Information

Chemical Name:Methyl-{5-methyl-2-[(E)-methylimino]-1,2-dihydro-benzo[cd]indol-6-yl}-[4-(morpholine-4-sulfonyl)-benzyl]-amine
CAS No.:138384-87-9
Molecular Formula:C₂₅H₂₈N₄O₃S
Molecular Weight:464.588
Hs Code.:

Synonyms:

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Chemical Property of Methyl-{5-methyl-2-[(E)-methylimino]-1,2-dihydro-benzo[cd]indol-6-yl}-[4-(morpholine-4-sulfonyl)-benzyl]-amine

Chemical Property:

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Technology Process of Methyl-{5-methyl-2-[(E)-methylimino]-1,2-dihydro-benzo[cd]indol-6-yl}-[4-(morpholine-4-sulfonyl)-benzyl]-amine

There total 11 articles about Methyl-{5-methyl-2-[(E)-methylimino]-1,2-dihydro-benzo[cd]indol-6-yl}-[4-(morpholine-4-sulfonyl)-benzyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4527-60-0
5-methyl-1-naphthoic acid

: 138384-87-9
Methyl-{5-methyl-2-[(E)-methylimino]-1,2-dihydro-benzo[cd]indol-6-yl}-[4-(morpholine-4-sulfonyl)-benzyl]-amine

Guidance literature:: Multi-step reaction with 11 steps

1: TEA / acetone / 0.5 h / -5 °C

2: NaN₃ / acetone; H₂O / 0.5 h / -5 °C

3: chlorobenzene / 132 °C

4: BCl₃ / nitrobenzene / 28 h / 110 - 115 °C

5: 57.2 percent / 70percent HNO₃ / acetic acid / 2 h / 50 °C

6: Raney nickel, hydrazine / tetrahydrofuran / 1.5 h / Heating

7: 96 percent / DIEA / dimethylformamide / 3.5 h / 62 °C

8: 79 percent / DIEA / dimethylformamide / 6 h / 67 °C

9: Lawesson's reagent / toluene

10: NaOH / tetrahydrofuran; ethanol

11: methanol

With Lawessons reagent; sodium hydroxide; sodium azide; TEA; nitric acid; boron trichloride; nickel; N-ethyl-N,N-diisopropylamine; hydrazine; In tetrahydrofuran; methanol; ethanol; water; acetic acid; nitrobenzene; N,N-dimethyl-formamide; chlorobenzene; acetone; toluene;
DOI:10.1021/jm00082a006

Reference yield:

: 1-Isocyanato-5-methyl-naphthalene

: 138384-87-9
Methyl-{5-methyl-2-[(E)-methylimino]-1,2-dihydro-benzo[cd]indol-6-yl}-[4-(morpholine-4-sulfonyl)-benzyl]-amine

Guidance literature:: Multi-step reaction with 8 steps

1: BCl₃ / nitrobenzene / 28 h / 110 - 115 °C

2: 57.2 percent / 70percent HNO₃ / acetic acid / 2 h / 50 °C

3: Raney nickel, hydrazine / tetrahydrofuran / 1.5 h / Heating

4: 96 percent / DIEA / dimethylformamide / 3.5 h / 62 °C

5: 79 percent / DIEA / dimethylformamide / 6 h / 67 °C

6: Lawesson's reagent / toluene

7: NaOH / tetrahydrofuran; ethanol

8: methanol

With Lawessons reagent; sodium hydroxide; nitric acid; boron trichloride; nickel; N-ethyl-N,N-diisopropylamine; hydrazine; In tetrahydrofuran; methanol; ethanol; acetic acid; nitrobenzene; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00082a006

Reference yield:

: 138384-90-4
5-methylbenzindol-2(1H)-one

: 138384-87-9
Methyl-{5-methyl-2-[(E)-methylimino]-1,2-dihydro-benzo[cd]indol-6-yl}-[4-(morpholine-4-sulfonyl)-benzyl]-amine

Guidance literature:: Multi-step reaction with 7 steps

1: 57.2 percent / 70percent HNO₃ / acetic acid / 2 h / 50 °C

2: Raney nickel, hydrazine / tetrahydrofuran / 1.5 h / Heating

3: 96 percent / DIEA / dimethylformamide / 3.5 h / 62 °C

4: 79 percent / DIEA / dimethylformamide / 6 h / 67 °C

5: Lawesson's reagent / toluene

6: NaOH / tetrahydrofuran; ethanol

7: methanol

With Lawessons reagent; sodium hydroxide; nitric acid; nickel; N-ethyl-N,N-diisopropylamine; hydrazine; In tetrahydrofuran; methanol; ethanol; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00082a006