potassium 7α-phenylacetamido-3-cyano-3-cephem-4-carboxylate

Base Information

Chemical Name:potassium 7α-phenylacetamido-3-cyano-3-cephem-4-carboxylate
CAS No.:128989-85-5
Molecular Formula:C₁₆H₁₂N₃O₄S*K
Molecular Weight:381.453
Hs Code.:

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Chemical Property of potassium 7α-phenylacetamido-3-cyano-3-cephem-4-carboxylate

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Technology Process of potassium 7α-phenylacetamido-3-cyano-3-cephem-4-carboxylate

There total 7 articles about potassium 7α-phenylacetamido-3-cyano-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128989-95-7
diphenylmethyl 7α-phenylacetamido-3-cyano-3-cephem-4-carboxylate

: 128989-85-5
potassium 7α-phenylacetamido-3-cyano-3-cephem-4-carboxylate

Guidance literature:: With diethylaluminium chloride; methoxybenzene; In hexane; dichloromethane; Yield given;
DOI:10.1246/bcsj.63.412

Reference yield:

: 90467-27-9
diphenylmethyl 7β-(o-hydroxybenzylideneamino)-3-hydroxymethyl-3-cephem-4-carboxylate

: 128989-85-5
potassium 7α-phenylacetamido-3-cyano-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 70 percent / imidazole / dimethylformamide / 0.5 h / -20 °C

2: 1) N,N-diisopropylethylamine, 2) Girard's reagent T / 1) THF, 4 deg C, 12.5 h, 2) methanol/ethyl acetate, 0 deg C, 1 h

3: 1) 1,3-bis(trimethylsilyl)urea / 1) THF, room temp., 1 h, 2) -15 deg C, 30 min

4: 1) boron trifluoride etherate, 2) Collins reagent / 1) acetonitrile, -25 deg C, 2) dichloromethane, room temp.

5: 90 percent / hydroxylamine hydrochloride / tetrahydrofuran; H₂O / 60 - 65 °C

6: 46 percent / phosphoryl chloride, DMF / ethyl acetate / Ambient temperature

7: diethylaluminum chloride, anisole / CH₂Cl₂; hexane

With 1H-imidazole; Collins oxidation agent; N,N'-bis(trimethylsilyl)urea; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; diethylaluminium chloride; girard's reagent T; methoxybenzene; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trichlorophosphate; In tetrahydrofuran; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.63.412

Reference yield:

: 128989-93-5
diphenylmethyl 7α-phenylacetamido-3-formyl-3-cephem-4-carboxylate

: 128989-85-5
potassium 7α-phenylacetamido-3-cyano-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / hydroxylamine hydrochloride / tetrahydrofuran; H₂O / 60 - 65 °C

2: 46 percent / phosphoryl chloride, DMF / ethyl acetate / Ambient temperature

3: diethylaluminum chloride, anisole / CH₂Cl₂; hexane

With hydroxylamine hydrochloride; diethylaluminium chloride; methoxybenzene; N,N-dimethyl-formamide; trichlorophosphate; In tetrahydrofuran; hexane; dichloromethane; water; ethyl acetate;
DOI:10.1246/bcsj.63.412